Seroatlas · Human Serome Atlas

GNAI2

Guanine nucleotide-binding protein G(i) subunit alpha-2

Also known as: GIP, GNAI2_HUMAN, GNAI2B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04899
Gene
GNAI2
Ensembl
ENSG00000114353
Chromosome
3
Canonical length
355 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>P04899|GNAI2
     1  MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEDG
    61  YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADPSR ADDARQLFAL SCTAEEQGVL
   121  PDDLSGVIRR LWADHGVQAC FGRSREYQLN DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV
   181  KTTGIVETHF TFKDLHFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE
   241  MNRMHESMKL FDSICNNKWF TDTSIILFLN KKDLFEEKIT HSPLTICFPE YTGANKYDEA
   301  ASYIQSKFED LNKRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK DCGLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNAI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
347 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 347 nTPM
  • spinal cord: 289 nTPM
  • lung: 271 nTPM
  • blood vessel: 260 nTPM
  • spleen: 260 nTPM
  • adipose tissue: 252 nTPM

Single-cell type

  • neutrophils: 1,060 nCPM
  • monocytes: 676 nCPM
  • monocyte progenitors: 498 nCPM
  • late spermatids: 488 nCPM
  • hofbauer cells: 484 nCPM
  • neutrophil progenitors: 445 nCPM

Immune cell

  • neutrophil: 146 nTPM
  • eosinophil: 114 nTPM
  • intermediate monocyte: 81 nTPM
  • non-classical monocyte: 75 nTPM
  • classical monocyte: 59 nTPM
  • myeloid DC: 57 nTPM

Brain region

  • medulla oblongata: 271 nTPM
  • white matter: 247 nTPM
  • hypothalamus: 238 nTPM
  • thalamus: 219 nTPM
  • spinal cord: 214 nTPM
  • pons: 208 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNAI2.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.89
gnomAD missense Z
3.15
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNAI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNAI2 as an antibody target. Whether an autoantibody or antibody against GNAI2 could matter depends on whether native GNAI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNAI2 is annotated at the cell surface, where native GNAI2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNAI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNAI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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