Seroatlas · Human Serome Atlas

RAB6C

Ras-related protein Rab-6C

Also known as: RAB6C_HUMAN, WTH3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0N0
Gene: RAB6C
Ensembl: ENSG00000222014
Chromosome: 2
Canonical length: 254 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Basal body

OverviewNCBI Gene

Enables GTPase activity. Involved in mitotic cell cycle; regulation of centrosome duplication; and response to xenobiotic stimulus. Located in Golgi apparatus; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9H0N0|RAB6C
     1  MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF LSKTMYLEDG
    61  TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI
   121  ITLVGNRTDL ADKRQVSVEE GERKAKGLNV TFIETRAKAG YNVKQLFRRV AAALPGMEST
   181  QDGSREDMSD IKLEKPQEQT VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL
   241  ITFCNSSLLP VSWR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 3.4 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 3.4 nTPM
breast: 2.3 nTPM
cerebral cortex: 1.9 nTPM
cervix: 1.7 nTPM
hippocampal formation: 1.7 nTPM
prostate: 1.7 nTPM

Single-cell type

epicardial cells: 16 nCPM
oligodendrocytes: 4.5 nCPM
breast hormone-responsive cells: 1.6 nCPM
prostatic glandular cells: 1.5 nCPM
endometrial stromal cells: 1.4 nCPM
early primary spermatocytes: 1.3 nCPM

Immune cell

gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 10 nTPM
basal ganglia: 6.2 nTPM
cerebral cortex: 5.9 nTPM
hypothalamus: 5.7 nTPM
thalamus: 4.6 nTPM
medulla oblongata: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB6C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GDI1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB6C as an antibody target. Whether an autoantibody or antibody against RAB6C could matter depends on whether native RAB6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB6C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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