Seroatlas · Human Serome Atlas

SRPRA

Signal recognition particle receptor subunit alpha

Also known as: SR-alpha, Sralpha, SRP-alpha, SRPR, SRPRA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08240
Gene
SRPRA
Ensembl
ENSG00000182934
Chromosome
11
Canonical length
638 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>P08240|SRPRA
     1  MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE ALTLKYKLDN
    61  QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ QSALSLLNGT FDFQNDFLRL
   121  LREAEESSKI RAPTTMKKFE DSEKAKKPVR SMIETRGEKP KEKAKNSKKK GAKKEGSDGP
   181  LATSKPVPAE KSGLPVGPEN GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK
   241  GKKAPRVWEL GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD
   301  EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI AKNVAADIAV
   361  QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ RRVDMLRDIM DAQRRQRPYV
   421  VTFCGVNGVG KSTNLAKISF WLLENGFSVL IAACDTFRAG AVEQLRTHTR RLSALHPPEK
   481  HGGRTMVQLF EKGYGKDAAG IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT
   541  VNTPDLVLFV GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA
   601  ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRPRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
249 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 249 nTPM
  • salivary gland: 223 nTPM
  • liver: 160 nTPM
  • epididymis: 136 nTPM
  • stomach: 94 nTPM
  • skeletal muscle: 89 nTPM

Single-cell type

  • plasma cells: 202 nCPM
  • salivary acinar cells: 170 nCPM
  • pancreatic acinar cells: 129 nCPM
  • breast lactating cells: 127 nCPM
  • lacrimal acinar cells: 122 nCPM
  • syncytiotrophoblasts: 113 nCPM

Immune cell

  • eosinophil: 96 nTPM
  • total PBMC: 95 nTPM
  • gdT-cell: 92 nTPM
  • non-classical monocyte: 83 nTPM
  • MAIT T-cell: 80 nTPM
  • plasmacytoid DC: 78 nTPM

Brain region

  • choroid plexus: 96 nTPM
  • cerebral cortex: 53 nTPM
  • thalamus: 52 nTPM
  • hypothalamus: 48 nTPM
  • medulla oblongata: 47 nTPM
  • pons: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRPRA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 39 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.78
DepMap mean gene effect
-0.71
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRPRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRPRA as an antibody target. Whether an autoantibody or antibody against SRPRA could matter depends on whether native SRPRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRPRA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRPRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRPRA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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