Seroatlas · Human Serome Atlas

TDRD12

Putative ATP-dependent RNA helicase TDRD12

Also known as: ECAT8, FLJ13072, TDR12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q587J7
Gene: TDRD12
Ensembl: ENSG00000173809
Chromosome: 19
Canonical length: 1177 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in several processes, including germ-line stem cell division; male meiotic nuclear division; and regulatory ncRNA-mediated gene silencing. Predicted to be part of PET complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1177 residues, UniProt reviewed canonical sequence.

>Q587J7|TDRD12
     1  MLQLLVLKIE DPGCFWVIIK GCSPFLDHDV DYQKLNSAMN DFYNSTCQDI EIKPLTLEEG
    61  QVCVVYCEEL KCWCRAIVKS ITSSADQYLA ECFLVDFAKN IPVKSKNIRV VVESFMQLPY
   121  RAKKFSLYCT KPVTLHIDFC RDSTDIVPAK KWDNAAIQYF QNLLKATTQV EARLCAVEED
   181  TFEVYLYVTI KDEKVCVNDD LVAKNYACYM SPTKNKNLDY LEKPRLNIKS APSFNKLNPA
   241  LTLWPMFLQG KDVQGMEDSH GVNFPAQSLQ HTWCKGIVGD LRPTATAQDK AVKCNMDSLR
   301  DSPKDKSEKK HHCISLKDTN KRVESSVYWP AKRGITIYAD PDVPEASALS QKSNEKPLRL
   361  TEKKEYDEKN SCVKLLQFLN PDPLRADGIS DLQQLQKLKG LQPPVVVLRN KIKPCLTIDS
   421  SPLSADLKKA LQRNKFPGPS HTESYSWPPI ARGCDVVVIS HCESNPLLYL LPVLTVLQTG
   481  ACYKSLPSRN GPLAVIVCPG WKKAQFIFEL LGEYSMSSRP LHPVLLTIGL HKEEAKNTKL
   541  PRGCDVIVTT PYSLLRLLAC QSLLFLRLCH LILDEVEVLF LEANEQMFAI LDNFKKNIEV
   601  EERESAPHQI VAVGVHWNKH IEHLIKEFMN DPYIVITAME EAALYGNVQQ VVHLCLECEK
   661  TSSLLQALDF IPSQAQKTLI FTCSVAETEI VCKVVESSSI FCLKMHKEMI FNLQNVLEQW
   721  KKKLSSGSQI ILALTDDCVP LLAITDATCV IHFSFPASPK VFGGRLYCMS DHFHAEQGSP
   781  AEQGDKKAKS VLLLTEKDAS HAVGVLRYLE RADAKVPAEL YEFTAGVLEA KEDKKAGRPL
   841  CPYLKAFGFC KDKRICPDRH RINPETDLPR KLSSQALPSF GYIKIIPFYI LNATNYFGRI
   901  VDKHMDLYAT LNAEMNEYFK DSNKTTVEKV EKFGLYGLAE KTLFHRVQVL EVNQKEDAWA
   961  LDDILVEFID EGRTGLVTRD QLLHLPEHFH TLPPQAVEFI VCRVKPADNE IEWNPKVTRY
  1021  IHHKIVGKLH DAKVILALGN TVWIDPMVHI TNLSSLKTSV IDYNVRAEIL SMGMGIDNPE
  1081  HIEQLKKLRE DAKIPACEES LSQTPPRVTG TSPAQDQDHP SEEQGGQGTP PAEDAACLQS
  1141  PQPEDTGAEG GAESKTSSEN QKPGGYLVFK RWLSSNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRD12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
epididymis: 3.1 nTPM
ovary: 0.9 nTPM
endometrium: 0.8 nTPM
skin: 0.8 nTPM
adrenal gland: 0.6 nTPM

Single-cell type

early primary spermatocytes: 107 nCPM
differentiating spermatogonia: 87 nCPM
undifferentiated spermatogonia: 66 nCPM
late primary spermatocytes: 47 nCPM
oocytes: 46 nCPM
epididymal principal cells: 27 nCPM

Immune cell

naive CD8 T-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 1.8 nTPM
medulla oblongata: 1.2 nTPM
cerebral cortex: 1.1 nTPM
pons: 1.1 nTPM
basal ganglia: 1 nTPM
cerebellum: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TDRD12.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 78 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fertilization
male meiotic nuclear division
piRNA processing
spermatogenesis
transposable element silencing by piRNA-mediated DNA methylation
germ-line stem cell division

Molecular functions

Cellular components

PET complex

Protein domainsUniProt · Pfam · InterPro

Tudor domain
DEAD/DEAH-box helicase domain
P-loop containing nucleoside triphosphate hydrolase
SNase-like, OB-fold superfamily
DEAD/DEAH box helicase
Tudor domain
Tudor domain-containing protein 12, first Tudor domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TDRD12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRD12 as an antibody target. Whether an autoantibody or antibody against TDRD12 could matter depends on whether native TDRD12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRD12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRD12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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