Seroatlas · Human Serome Atlas

NUGGC

Nuclear GTPase SLIP-GC

Also known as: C8orf80, HMFN0672, SLIP_HUMAN, SLIP-GC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CJ6
Gene: NUGGC
Ensembl: ENSG00000189233
Chromosome: 8
Canonical length: 796 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables GTPase activity. Involved in cellular response to lipopolysaccharide; negative regulation of apoptotic process; and regulation of nuclear cell cycle DNA replication. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

796 residues, UniProt reviewed canonical sequence.

>Q68CJ6|NUGGC
     1  MAETKDVFGQ EPHPVEDDLY KERTRKRRKS DRDQRFRAFP SMEQSALKEY EKLESRTRRV
    61  LSNTYQKLIQ SVFLDDSIPN GVKYLINRLL ALIEKPTVDP IYIALFGSTG AGKSSLINAI
   121  IQQAMFLPVS GESICTSCIV QVSSGCCVQY EAKIHLLSDQ EWREELKNLT KLLHRTEELS
   181  REEADAWNRD EAVEEATWKL QMIYGNGAES KNYEELLRAK PKRKIPTSRV ITLKAEEAEE
   241  LSIKLDPYIR TQRRDWDGEA AEMRIWPLIK HVEVTLPKSD LIPEGVVLVD IPGTGDFNSK
   301  RDEMWKKTID KCSVIWVISD IERVSGGQAH EDLLNESIKA CQRGFCRDVA LVVTKMDKLH
   361  LPEYLRERKA GNQAIQSQRE AVLERNEMIK LQRTRILKEK LKRKLPADFK VLEASDLVYT
   421  VSAQEYWQQA LLTEEETEIP KLREYIRKSL LDKKKRTVTK YVTEAFGLLL LTDSFNSTQN
   481  LPNEHLHMSV LRRFAEEKVE LLEKAIAQCF ACMEQPLQEG VRTARTSYRC ILRACLVRSK
   541  GNQGFHQTLK AVCLKNGIYA SRTLARIDLN EALTQPVYDQ IDPVFGSIFR TGKPTGSALM
   601  PHIDAFKQSL QEKMTEIGIR SGWKYDSCKK NFLIQEISAI LGGLEDHILR RKRRIYESLT
   661  ASVQSDLKLC YEEAAQITGK KACERMKDAI RRGVDRQVAE GMFERAQERM QHQFQQLKTG
   721  IVEKVKGSIT TMLALASSQG DGLYKELADV GSEYKEMEKL HRSLREVAEN ARLRKGMQEF
   781  LLRASPSKAG PPGTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUGGC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

tonsil: 21 nTPM
liver: 19 nTPM
lymph node: 17 nTPM
appendix: 5.9 nTPM
kidney: 4.7 nTPM
spleen: 2.5 nTPM

Single-cell type

plasma cells: 151 nCPM
hepatocytes: 84 nCPM
proximal tubule cells: 54 nCPM
t-cells: 21 nCPM
mesothelial cells: 17 nCPM
epicardial cells: 16 nCPM

Immune cell

gdT-cell: 4 nTPM
memory CD8 T-cell: 2.6 nTPM
memory CD4 T-cell: 1.8 nTPM
memory B-cell: 1.6 nTPM
basophil: 1 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

white matter: 10 nTPM
choroid plexus: 9.2 nTPM
cerebral cortex: 8.2 nTPM
medulla oblongata: 7.1 nTPM
pons: 7 nTPM
midbrain: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Dynamin, N-terminal
Dynamin family
Nuclear GTPase SLIP-GC

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUGGC as an antibody target. Whether an autoantibody or antibody against NUGGC could matter depends on whether native NUGGC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUGGC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUGGC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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