CHD6

Protein identityUniProt · HPA

UniProt accession

Q8TD26

Gene

CHD6

Ensembl

ENSG00000124177

Chromosome

20

Canonical length

2715 aa

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

2715 residues, UniProt reviewed canonical sequence.

>Q8TD26|CHD6
     1  MKMKIQKKEK QLSNLKVLNH SPMSDASVNF DYKSPSPFDC STDQEEKIED VASHCLPQKD
    61  LYTAEEEAAT LFPRKMTSHN GMEDSGGGGT GVKKKRKKKE PGDQEGAAKG SKDREPKPKR
   121  KREPKEPKEP RKAKEPKKAK EHKEPKQKDG AKKARKPREA SGTKEAKEKR SCTDSAARTK
   181  SRKASKEQGP TPVEKKKKGK RKSETTVESL ELDQGLTNPS LRSPEESTES TDSQKRRSGR
   241  QVKRRKYNED LDFKVVDDDG ETIAVLGAGR TSALSASTLA WQAEEPPEDD ANIIEKILAS
   301  KTVQEVHPGE PPFDLELFYV KYRNFSYLHC KWATMEELEK DPRIAQKIKR FRNKQAQMKH
   361  IFTEPDEDLF NPDYVEVDRI LEVAHTKDAE TGEEVTHYLV KWCSLPYEES TWELEEDVDP
   421  AKVKEFESLQ VLPEIKHVER PASDSWQKLE KSREYKNSNQ LREYQLEGMN WLLFNWYNRK
   481  NCILADEMGL GKTIQSITFL SEIFLRGIHG PFLIIAPLST ITNWEREFRT WTEMNAIVYH
   541  GSQISRQMIQ QYEMVYRDAQ GNPLSGVFKF HVVITTFEMI LADCPELKKI HWSCVIIDEA
   601  HRLKNRNCKL LEGLKLMALE HKVLLTGTPL QNSVEELFSL LNFLEPSQFP SETAFLEEFG
   661  DLKTEEQVKK LQSILKPMML RRLKDDVEKN LAPKQETIIE VELTNIQKKY YRAILEKNFS
   721  FLTKGANQHN MPNLINTMME LRKCCNHPYL INGAEEKILE DFRKTHSPDA PDFQLQAMIQ
   781  AAGKLVLIDK LLPKLIAGGH KVLIFSQMVR CLDILEDYLI QRRYTYERID GRVRGNLRQA
   841  AIDRFCKPDS DRFVFLLCTR AGGLGINLTA ADTCIIFDSD WNPQNDLQAQ ARCHRIGQSK
   901  AVKVYRLITR NSYEREMFDK ASLKLGLDKA VLQDINRKGG TNGVQQLSKM EVEDLLRKGA
   961  YGALMDEEDE GSKFCEEDID QILQRRTHTI TIQSEGKGST FAKASFVASG NRTDISLDDP
  1021  NFWQKWAKIA ELDTEAKNEK ESLVIDRPRV RKQTKHYNSF EEDELMEFSE LDSDSDERPT
  1081  RSRRLNDKAR RYLRAECFRV EKNLLIFGWG RWKDILTHGR FKWHLNEKDM EMICRALLVY
  1141  CVKHYKGDEK IKSFIWELIT PTKDGQAQTL QNHSGLSAPV PRGRKGKKTK NQLLIPELKD
  1201  ADWLATCNPE VVLHDDGYKK HLKQHCNKVL LRVRMLYYLK AEILGEAAEK AFEGSPAREL
  1261  DVPLPDIDYM EIPVDWWDAE ADKSLLIGVF KHGYERYNAM RADPALCFLE KVGMPDEKSL
  1321  SAEQGVTDGT SDIPERGNTD KEDNAEDKVD GLQKQTESSS DGGDGVFSEK KDDSRAAQDG
  1381  SDPDKSPWPV SSALTARLRR LVTVYQRCNR KELCRPEILG PGNQGYWVQE EMFRRTSEMD
  1441  LINKEAQKRW TRREQADFYR TVSSFGVVYD QEKKTFDWTQ FRIISRLDKK SDESLEQYFY
  1501  SFVAMCRNVC RLPTWKDGGP PDTTIYVEPI TEERAARTLY RIELLRKVRE QVLKCPQLHE
  1561  RLQLCRPSLY LPVWWECGKH DRDLLIGTAK HGLNRTDCYI MNDPQLSFLD AYRNYAQHKR
  1621  SGTQAPGNLC CLYQTNSKLY ESLTYSQMSR TSESLENEPE NLVRVESRDD HLSLPDVTCE
  1681  NFISKVQDVI SINHDESLLP ESLESMMYGK KVLSQEPSSF QESPSTNTES RKDVITISIS
  1741  KDGNCQSGGP EAEIASGPTF MGSLEAGGVA QANIKNGKHL LMSISKEGEL CCSEAGQRPE
  1801  NIGQLEAKCL ASPSLNPGNE SGFVDMCSLS VCDSKRNLSS DQQLIDLLEN KSLESKLILS
  1861  QNHSDEEEEE EENEEENLAM AVGMGERPEV LHLTEPTTNI SREKNQGFQD ETKKGSLEVA
  1921  NQTPGLQRAF PAPAACQCHC KHMERWMHGL ENDEFEIEKP KAYIPDLFKS KTNTIAMEGE
  1981  PTAIPSQPFK VKHELLKEPW KESAEGQNVF PTYPLEGSEL KSEDMDFENK DDYDRDGNCH
  2041  SQDYPGKYSE EESKSSTSGI TGDIGDELQE ARAPTIAQLL QEKTLYSFSE WPKDRVIINR
  2101  LDNICHVVLK GKWPSSQQYE PSGTLPTPVL TSSAGSRTSL SEPEAAEHSF SNGAALAAQI
  2161  HKESFLAPVF TKDEQKHRRP YEFEVERDAK ARGLEQFSAT HGHTPIILNG WHGESAMDLS
  2221  CSSEGSPGAT SPFPVSASTP KIGAISSLQG ALGMDLSGIL QAGLIHPVTG QIVNGSLRRD
  2281  DAATRRRRGR RKHVEGGMDL IFLKEQTLQA GILEVHEDPG QATLSTTHPE GPGPATSAPE
  2341  PATAASSQAE KSIPSKSLLD WLRQQADYSL EVPGFGANFS DKPKQRRPRC KEPGKLDVSS
  2401  LSGEERVPAI PKEPGLRGFL PENKFNHTLA EPILRDTGPR RRGRRPRSEL LKAPSIVADS
  2461  PSGMGPLFMN GLIAGMDLVG LQNMRNMPGI PLTGLVGFPA GFATMPTGEE VKSTLSMLPM
  2521  MLPGMAAVPQ MFGVGGLLSP PMATTCTSTA PASLSSTTKS GTAVTEKTAE DKPSSHDVKT
  2581  DTLAEDKPGP GPFSDQSEPA ITTSSPVAFN PFLIPGVSPG LIYPSMFLSP GMGMALPAMQ
  2641  QARHSEIVGL ESQKRKKKKT KGDNPNSHPE PAPSCEREPS GDENCAEPSA PLPAEREHGA
  2701  QAGEGALKDS NNDTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

16 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHD6.

Disease | ImmuneIEDB

Conditions an epitope on CHD6 was assayed in.

• glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.07

gnomAD pLI

1

gnomAD missense Z

4

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• chromatin remodeling
• positive regulation of transcription by RNA polymerase II
• regulation of gene expression

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATP-dependent activity, acting on DNA
• ATP-dependent chromatin remodeler activity
• chromatin binding
• DNA binding
• histone binding
• transcription coregulator binding

Cellular components

• chromatin
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• SNF2, N-terminal domain
• Chromo/chromo shadow domain
• Helicase, C-terminal domain-like
• DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
• BRK domain
• Helicase superfamily 1/2, ATP-binding domain
• Chromo-like domain superfamily
• Chromo domain
• P-loop containing nucleoside triphosphate hydrolase
• BRK domain superfamily
• SNF2-like, N-terminal domain superfamily
• SNF2/RAD5-like, C-terminal helicase domain
• Chromodomain-helicase-DNA-binding
• Chromodomain-helicase-DNA-binding protein 6-9, tri-helical domain
• SNF2-related domain
• Helicase conserved C-terminal domain
• Chromo (CHRromatin Organisation MOdifier) domain
• Chromodomain-helicase-DNA-binding protein 6-9, tri-helical

KeywordsUniProt

• ATP-binding
• Chromatin regulator
• DNA-binding
• Host-virus interaction
• Hydrolase
• Nucleotide-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of CHD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NFE2L2
• PA
• PB2