Seroatlas · Human Serome Atlas

DDX52

Probable ATP-dependent RNA helicase DDX52

Also known as: DDX52_HUMAN, ROK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2R4
Gene: DDX52
Ensembl: ENSG00000278053
Chromosome: 17
Canonical length: 599 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>Q9Y2R4|DDX52
     1  MDVHDLFRRL GAGAKFDTRR FSADAARFQI GKRKYDFDSS EVLQGLDFFG NKKSVPGVCG
    61  ASQTHQKPQN GEKKEESLTE RKREQSKKKR KTMTSEIASQ EEGATIQWMS SVEAKIEDKK
   121  VQRESKLTSG KLENLRKEKI NFLRNKHKIH VQGTDLPDPI ATFQQLDQEY KINSRLLQNI
   181  LDAGFQMPTP IQMQAIPVML HGRELLASAP TGSGKTLAFS IPILMQLKQP ANKGFRALII
   241  SPTRELASQI HRELIKISEG TGFRIHMIHK AAVAAKKFGP KSSKKFDILV TTPNRLIYLL
   301  KQDPPGIDLA SVEWLVVDES DKLFEDGKTG FRDQLASIFL ACTSHKVRRA MFSATFAYDV
   361  EQWCKLNLDN VISVSIGARN SAVETVEQEL LFVGSETGKL LAVRELVKKG FNPPVLVFVQ
   421  SIERAKELFH ELIYEGINVD VIHAERTQQQ RDNTVHSFRA GKIWVLICTA LLARGIDFKG
   481  VNLVINYDFP TSSVEYIHRI GRTGRAGNKG KAITFFTEDD KPLLRSVANV IQQAGCPVPE
   541  YIKGFQKLLS KQKKKMIKKP LERESISTTP KCFLEKAKDK QKKVTGQNSK KKVALEDKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4 nTPM
epididymis: 3.6 nTPM
cerebellum: 3.5 nTPM
small intestine: 3.1 nTPM
esophagus: 3 nTPM
pancreas: 2.8 nTPM

Single-cell type

early spermatids: 195 nCPM
endometrial glandular cells: 160 nCPM
renal collecting duct intercalated cells: 103 nCPM
late spermatids: 92 nCPM
loop of henle epithelial cells: 63 nCPM
endometrial luminal cells: 59 nCPM

Immune cell

plasmacytoid DC: 1.1 nTPM
naive CD8 T-cell: 0.9 nTPM
basophil: 0.8 nTPM
gdT-cell: 0.8 nTPM
NK-cell: 0.8 nTPM
eosinophil: 0.7 nTPM

Brain region

cerebellum: 6.8 nTPM
choroid plexus: 6.6 nTPM
white matter: 6.5 nTPM
pons: 6.1 nTPM
cerebral cortex: 5.9 nTPM
thalamus: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maturation of SSU-rRNA

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX52 as an antibody target. Whether an autoantibody or antibody against DDX52 could matter depends on whether native DDX52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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