Seroatlas · Human Serome Atlas

PSMC4

26S proteasome regulatory subunit 6B

Also known as: MGC13687, MGC23214, MGC8570, MIP224, PRS6B_HUMAN, RPT3, S6, TBP-7, TBP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43686
Gene
PSMC4
Ensembl
ENSG00000013275
Chromosome
19
Canonical length
418 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Basal body,Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>P43686|PSMC4
     1  MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY
    61  IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID
   121  RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA
   181  VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL
   241  GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD
   301  QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL
   361  EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 100 nTPM
  • liver: 61 nTPM
  • heart muscle: 53 nTPM
  • adrenal gland: 48 nTPM
  • esophagus: 47 nTPM
  • kidney: 43 nTPM

Single-cell type

  • syncytiotrophoblasts: 322 nCPM
  • late primary spermatocytes: 237 nCPM
  • early spermatids: 156 nCPM
  • hofbauer cells: 146 nCPM
  • late spermatids: 140 nCPM
  • cytotrophoblasts: 132 nCPM

Immune cell

  • non-classical monocyte: 90 nTPM
  • myeloid DC: 67 nTPM
  • intermediate monocyte: 65 nTPM
  • total PBMC: 62 nTPM
  • T-reg: 60 nTPM
  • memory CD8 T-cell: 47 nTPM

Brain region

  • white matter: 32 nTPM
  • pons: 31 nTPM
  • hypothalamus: 30 nTPM
  • spinal cord: 28 nTPM
  • medulla oblongata: 27 nTPM
  • cerebellum: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.3
gnomAD missense Z
3.53
DepMap mean gene effect
-1.48
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMC4 as an antibody target. Whether an autoantibody or antibody against PSMC4 could matter depends on whether native PSMC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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