Seroatlas · Human Serome Atlas

CHTF18

Chromosome transmission fidelity protein 18 homolog

Also known as: C16orf41, C321D2.4, CHL12, Ctf18, CTF18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVB6
Gene
CHTF18
Ensembl
ENSG00000127586
Chromosome
16
Canonical length
975 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

975 residues, UniProt reviewed canonical sequence.

>Q8WVB6|CHTF18
     1  MEDYEQELCG VEDDFHNQFA AELEVLAELE GASTPSPSGV PLFTAGRPPR TFEEALARGD
    61  AASSPAPAAS VGSSQGGARK RQVDADLQPA GSLPHAPRIK RPRLQVVKRL NFRSEEMEEP
   121  PPPDSSPTDI TPPPSPEDLA ELWGHGVSEA AADVGLTRAS PAARNPVLRR PPILEDYVHV
   181  TSTEGVRAYL VLRADPMAPG VQGSLLHVPW RGGGQLDLLG VSLASLKKQV DGERRERLLQ
   241  EAQKLSDTLH SLRSGEEEAA QPLGAPEEEP TDGQDASSHC LWVDEFAPRH YTELLSDDFT
   301  NRCLLKWLKL WDLVVFGHER PSRKPRPSVE PARVSKEATA PGKWKSHEQV LEEMLEAGLD
   361  PSQRPKQKVA LLCGPPGLGK TTLAHVIARH AGYSVVEMNA SDDRSPEVFR TRIEAATQME
   421  SVLGAGGKPN CLVIDEIDGA PVAAINVLLS ILNRKGPQEV GPQGPAVPSG GGRRRRAEGG
   481  LLMRPIICIC NDQFAPSLRQ LKQQAFLLHF PPTLPSRLVQ RLQEVSLRQG MRADPGVLAA
   541  LCEKTDNDIR ACINTLQFLY SRGQRELSVR DVQATRVGLK DQRRGLFSVW QEVFQLPRAQ
   601  RRRVGQDPAL PADTLLLGDG DAGSLTSASQ RFYRVLHAAA SAGEHEKVVQ GLFDNFLRLR
   661  LRDSSLGAVC VALDWLAFDD LLAGAAHHSQ SFQLLRYPPF LPVAFHVLFA SSHTPRITFP
   721  SSQQEAQNRM SQMRNLIQTL VSGIAPATRS RATPQALLLD ALCLLLDILA PKLRPVSTQL
   781  YSTREKQQLA SLVGTMLAYS LTYRQERTPD GQYIYRLEPN VEELCRFPEL PARKPLTYQT
   841  KQLIAREIEV EKMRRAEASA RVENSPQVDG SPPGLEGLLG GIGEKGVHRP APRNHEQRLE
   901  HIMRRAAREE QPEKDFFGRV VVRSTAVPSA GDTAPEQDSV ERRMGTAVGR SEVWFRFNEG
   961  VSNAVRRSLY IRDLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHTF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • cerebellum: 7.7 nTPM
  • bone marrow: 6.5 nTPM
  • spleen: 5.5 nTPM
  • esophagus: 4.9 nTPM
  • ovary: 4.7 nTPM

Single-cell type

  • retinal bipolar cells: 26 nCPM
  • differentiating spermatogonia: 25 nCPM
  • extravillous trophoblasts: 23 nCPM
  • erythrocyte progenitors: 21 nCPM
  • migrating cytotrophoblasts: 21 nCPM
  • undifferentiated spermatogonia: 21 nCPM

Immune cell

  • basophil: 2.5 nTPM
  • intermediate monocyte: 1 nTPM
  • gdT-cell: 0.7 nTPM
  • NK-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM

Brain region

  • cerebral cortex: 3.3 nTPM
  • amygdala: 2.9 nTPM
  • cerebellum: 2.8 nTPM
  • hippocampal formation: 2.7 nTPM
  • basal ganglia: 2.6 nTPM
  • hypothalamus: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
-3.79
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHTF18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHTF18 as an antibody target. Whether an autoantibody or antibody against CHTF18 could matter depends on whether native CHTF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHTF18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHTF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHTF18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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