Seroatlas · Human Serome Atlas

RASL11B

Ras-like protein family member 11B

Also known as: RSLBB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPW5
Gene: RASL11B
Ensembl: ENSG00000128045
Chromosome: 4
Canonical length: 248 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable G protein activity; GTP binding activity; and transforming growth factor beta receptor binding activity. Predicted to act upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q9BPW5|RASL11B
     1  MRLIQNMCTI AEYPAPGNAA ASDCCVGAAG RRLVKIAVVG ASGVGKTALV VRFLTKRFIG
    61  DYERNAGNLY TRQVQIEGET LALQVQDTPG IQVHENSLSC SEQLNRCIRW ADAVVIVFSI
   121  TDYKSYELIS QLHQHVQQLH LGTRLPVVVV ANKADLLHIK QVDPQLGLQL ASMLGCSFYE
   181  VSVSENYNDV YSAFHVLCKE VSHKQQPSST PEKRRTSLIP RPKSPNMQDL KRRFKQALSA
   241  KVRTVTSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASL11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

ovary: 64 nTPM
spleen: 28 nTPM
kidney: 17 nTPM
cerebellum: 16 nTPM
heart muscle: 14 nTPM
blood vessel: 13 nTPM

Single-cell type

podocytes: 53 nCPM
renal collecting duct principal cells: 14 nCPM
loop of henle epithelial cells: 8.2 nCPM
migrating cytotrophoblasts: 7.7 nCPM
epididymal basal cells: 6.8 nCPM
cytotrophoblasts: 5.8 nCPM

Immune cell

NK-cell: 0.5 nTPM
naive CD4 T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 12 nTPM
basal ganglia: 9.1 nTPM
hypothalamus: 8.9 nTPM
white matter: 8.4 nTPM
cerebellum: 7.6 nTPM
amygdala: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0.01
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transforming growth factor beta receptor signaling pathway

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASL11B as an antibody target. Whether an autoantibody or antibody against RASL11B could matter depends on whether native RASL11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASL11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASL11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...