Seroatlas · Human Serome Atlas

RAB3B

Ras-related protein Rab-3B

Also known as: RAB3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20337
Gene: RAB3B
Ensembl: ENSG00000169213
Chromosome: 1
Canonical length: 219 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

Enables GDP binding activity; GTPase activity; and myosin V binding activity. Involved in several processes, including positive regulation of dopamine uptake involved in synaptic transmission; regulation of synaptic vesicle cycle; and regulation of vesicle size. Located in perinuclear region of cytoplasm and vesicle. Is active in dopaminergic synapse and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>P20337|RAB3B
     1  MASVTDGKTG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA FVSTVGIDFK
    61  VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWATQI
   121  KTYSWDNAQV ILVGNKCDME EERVVPTEKG QLLAEQLGFD FFEASAKENI SVRQAFERLV
   181  DAICDKMSDS LDTDPSMLGS SKNTRLSDTP PLLQQNCSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

prostate: 10 nTPM
pituitary gland: 10 nTPM
hypothalamus: 9.5 nTPM
amygdala: 4.7 nTPM
cerebral cortex: 4.6 nTPM
adrenal gland: 2.8 nTPM

Single-cell type

corticotrophs: 1,075 nCPM
pancreatic islet cells: 270 nCPM
neuroendocrine cells: 200 nCPM
prostatic glandular cells: 182 nCPM
adrenal medulla cells: 85 nCPM
other brain neurons: 71 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

pons: 75 nTPM
hypothalamus: 57 nTPM
cerebral cortex: 57 nTPM
midbrain: 46 nTPM
thalamus: 39 nTPM
medulla oblongata: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.31
gnomAD missense Z: 0.94
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB3B as an antibody target. Whether an autoantibody or antibody against RAB3B could matter depends on whether native RAB3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB3B is annotated at the cell surface, where native RAB3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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