Seroatlas · Human Serome Atlas

DIRAS2

GTP-binding protein Di-Ras2

Also known as: Di-Ras2, DIRA2_HUMAN, DKFZp761C07121

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HU8
Gene
DIRAS2
Ensembl
ENSG00000165023
Chromosome
9
Canonical length
199 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q96HU8|DIRAS2
     1  MPEQSNDYRV AVFGAGGVGK SSLVLRFVKG TFRESYIPTV EDTYRQVISC DKSICTLQIT
    61  DTTGSHQFPA MQRLSISKGH AFILVYSITS RQSLEELKPI YEQICEIKGD VESIPIMLVG
   121  NKCDESPSRE VQSSEAEALA RTWKCAFMET SAKLNHNVKE LFQELLNLEK RRTVSLQIDG
   181  KKSKQQKRKE KLKGKCVIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIRAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
152 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 152 nTPM
  • cerebral cortex: 80 nTPM
  • retina: 37 nTPM
  • hippocampal formation: 28 nTPM
  • spinal cord: 15 nTPM
  • amygdala: 13 nTPM

Single-cell type

  • retinal bipolar cells: 126 nCPM
  • brain excitatory neurons: 113 nCPM
  • retinal amacrine cells: 91 nCPM
  • retinal horizontal cells: 66 nCPM
  • other brain neurons: 53 nCPM
  • rod photoreceptor cells: 46 nCPM

Immune cell

  • eosinophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • classical monocyte: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • cerebellum: 203 nTPM
  • cerebral cortex: 182 nTPM
  • white matter: 171 nTPM
  • basal ganglia: 127 nTPM
  • hippocampal formation: 120 nTPM
  • thalamus: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0.48
gnomAD missense Z
1.96
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIRAS2 as an antibody target. Whether an autoantibody or antibody against DIRAS2 could matter depends on whether native DIRAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIRAS2 is annotated at the cell surface, where native DIRAS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DIRAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DIRAS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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