DNAJC27
DnaJ homolog subfamily C member 27
Also known as: DJC27_HUMAN, RabJS, RBJ
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NZQ0
- Gene
- DNAJC27
- Ensembl
- ENSG00000115137
- Chromosome
- 2
- Canonical length
- 273 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be located in cytoplasmic vesicle and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
273 residues, UniProt reviewed canonical sequence.
>Q9NZQ0|DNAJC27
1 MEANMPKRKE PGRSLRIKVI SMGNAEVGKS CIIKRYCEKR FVSKYLATIG IDYGVTKVHV
61 RDREIKVNIF DMAGHPFFYE VRNEFYKDTQ GVILVYDVGQ KDSFDALDAW LAEMKQELGP
121 HGNMENIIFV VCANKIDCTK HRCVDESEGR LWAESKGFLY FETSAQTGEG INEMFQTFYI
181 SIVDLCENGG KRPTTNSSAS FTKEQADAIR RIRNSKDSWD MLGVKPGASR DEVNKAYRKL
241 AVLLHPDKCV APGSEDAFKA VVNARTALLK NIKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DNAJC27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- testis: 21 nTPM
- retina: 12 nTPM
- ovary: 6.8 nTPM
- tongue: 6.5 nTPM
- cerebellum: 6.2 nTPM
- midbrain: 6 nTPM
Single-cell type
- granulosa cells: 128 nCPM
- vascular smooth muscle cells: 110 nCPM
- late primary spermatocytes: 107 nCPM
- somatotrophs: 98 nCPM
- schwann cells: 97 nCPM
- ovarian stromal cells: 97 nCPM
Immune cell
- NK-cell: 1.3 nTPM
- eosinophil: 0.9 nTPM
- MAIT T-cell: 0.5 nTPM
- naive CD8 T-cell: 0.5 nTPM
- memory B-cell: 0.4 nTPM
- naive CD4 T-cell: 0.4 nTPM
Brain region
- hypothalamus: 19 nTPM
- pons: 19 nTPM
- medulla oblongata: 17 nTPM
- cerebellum: 16 nTPM
- cerebral cortex: 16 nTPM
- midbrain: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DNAJC27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DNAJC27 as an antibody target. Whether an autoantibody or antibody against DNAJC27 could matter depends on whether native DNAJC27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DNAJC27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DNAJC27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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