RAB17
Ras-related protein Rab-17
Also known as: RAB17_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H0T7
- Gene
- RAB17
- Ensembl
- ENSG00000124839
- Chromosome
- 2
- Canonical length
- 212 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]
Canonical amino-acid sequenceUniProt
212 residues, UniProt reviewed canonical sequence.
>Q9H0T7|RAB17
1 MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT VGCAFFTKVV
61 DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI TRKDSFLKAQ QWLKDLEEEL
121 HPGEVLVMLV GNKTDLSQER EVTFQEGKEF ADSQKLLFME TSAKLNHQVS EVFNTVAQEL
181 LQRSDEEGQA LRGDAAVALN KGPARQAKCC AHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 123 nTPM
Expression across tissuesHPA
Tissue
- liver: 123 nTPM
- kidney: 77 nTPM
- duodenum: 72 nTPM
- choroid plexus: 72 nTPM
- small intestine: 69 nTPM
- pancreas: 36 nTPM
Single-cell type
- enterocytes: 232 nCPM
- hepatocytes: 167 nCPM
- cone photoreceptor cells: 114 nCPM
- epididymal efferent duct absorptive cells: 108 nCPM
- parietal cells: 106 nCPM
- cholangiocytes: 81 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 54 nTPM
- hippocampal formation: 3.8 nTPM
- cerebral cortex: 1.1 nTPM
- thalamus: 1 nTPM
- amygdala: 0.9 nTPM
- medulla oblongata: 0.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.95
- gnomAD pLI
- 0.07
- gnomAD missense Z
- 0.07
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anterograde dendritic transport
- cilium assembly
- endocytic recycling
- establishment of melanosome localization
- filopodium assembly
- immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
- intracellular protein transport
- melanosome transport
- regulation of dendrite development
- regulation of filopodium assembly
- regulation of synapse assembly
- transcytosis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB17 as an antibody target. Whether an autoantibody or antibody against RAB17 could matter depends on whether native RAB17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RAB17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...