Seroatlas · Human Serome Atlas

ORC5

Origin recognition complex subunit 5

Also known as: ORC5_HUMAN, ORC5L, Orc5p, ORC5T, PPP1R117

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43913
Gene
ORC5
Ensembl
ENSG00000164815
Chromosome
7
Canonical length
435 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>O43913|ORC5
     1  MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF
    61  VNCVECFTLR LLLEQILNKL NHLSSSEDGC STEITCETFN DFVRLFKQVT TAENLKDQTV
   121  YIVLDKAEYL RDMEANLLPG FLRLQELADR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP
   181  DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV
   241  VKGEASERDT RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV
   301  ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD
   361  RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA
   421  RTVNFDIIKY LYDFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • liver: 16 nTPM
  • prostate: 16 nTPM
  • pancreas: 14 nTPM
  • retina: 13 nTPM
  • cerebellum: 13 nTPM

Single-cell type

  • oocytes: 129 nCPM
  • rod photoreceptor cells: 87 nCPM
  • adrenal cortex cells: 81 nCPM
  • gonadotrophs: 71 nCPM
  • brain inhibitory neurons: 70 nCPM
  • brain excitatory neurons: 69 nCPM

Immune cell

  • naive CD8 T-cell: 29 nTPM
  • MAIT T-cell: 27 nTPM
  • naive CD4 T-cell: 26 nTPM
  • memory B-cell: 24 nTPM
  • memory CD8 T-cell: 24 nTPM
  • memory CD4 T-cell: 22 nTPM

Brain region

  • cerebellum: 25 nTPM
  • cerebral cortex: 20 nTPM
  • basal ganglia: 19 nTPM
  • hypothalamus: 19 nTPM
  • thalamus: 19 nTPM
  • hippocampal formation: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
-0.52
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ORC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORC5 as an antibody target. Whether an autoantibody or antibody against ORC5 could matter depends on whether native ORC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ORC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ORC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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