Seroatlas · Human Serome Atlas

RAB35

Ras-related protein Rab-35

Also known as: H-ray, RAB35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15286
Gene: RAB35
Ensembl: ENSG00000111737
Chromosome: 12
Canonical length: 201 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables GTPase activity and anion binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q15286|RAB35
     1  MARDYDHLFK LLIIGDSGVG KSSLLLRFAD NTFSGSYITT IGVDFKIRTV EINGEKVKLQ
    61  IWDTAGQERF RTITSTYYRG THGVIVVYDV TSAESFVNVK RWLHEINQNC DDVCRILVGN
   121  KNDDPERKVV ETEDAYKFAG QMGIQLFETS AKENVNVEEM FNCITELVLR AKKDNLAKQQ
   181  QQQQNDVVKL TKNSKRKKRC C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

esophagus: 39 nTPM
skin: 35 nTPM
bone marrow: 34 nTPM
spleen: 31 nTPM
vagina: 27 nTPM
adipose tissue: 27 nTPM

Single-cell type

neutrophils: 110 nCPM
esophageal apical cells: 95 nCPM
syncytiotrophoblasts: 69 nCPM
hofbauer cells: 60 nCPM
esophageal suprabasal cells: 57 nCPM
cardiomyocytes: 56 nCPM

Immune cell

eosinophil: 15 nTPM
neutrophil: 14 nTPM
non-classical monocyte: 12 nTPM
intermediate monocyte: 8.2 nTPM
classical monocyte: 7.3 nTPM
memory CD8 T-cell: 7.2 nTPM

Brain region

thalamus: 34 nTPM
cerebral cortex: 33 nTPM
basal ganglia: 31 nTPM
midbrain: 31 nTPM
pons: 31 nTPM
hypothalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 0.98
gnomAD missense Z: 2.36
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB35 as an antibody target. Whether an autoantibody or antibody against RAB35 could matter depends on whether native RAB35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB35 is annotated at the cell surface, where native RAB35 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...