Seroatlas · Human Serome Atlas

DLG4

Disks large homolog 4

Also known as: DLG4_HUMAN, PSD-95, PSD95, SAP-90, SAP90

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78352
Gene
DLG4
Ensembl
ENSG00000132535
Chromosome
17
Canonical length
724 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>P78352|DLG4
     1  MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY ELQVNGTEGE
    61  MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV
   121  NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN
   181  QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY
   241  LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD
   301  LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL
   361  SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT
   421  ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS
   481  ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL
   541  GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE
   601  AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE
   661  INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA
   721  RERL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
211 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 211 nTPM
  • retina: 201 nTPM
  • basal ganglia: 192 nTPM
  • hippocampal formation: 175 nTPM
  • cerebellum: 164 nTPM
  • amygdala: 164 nTPM

Single-cell type

  • cone photoreceptor cells: 209 nCPM
  • rod photoreceptor cells: 142 nCPM
  • retinal bipolar cells: 65 nCPM
  • choroid plexus epithelial cells: 49 nCPM
  • brain inhibitory neurons: 42 nCPM
  • brain excitatory neurons: 40 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • cerebral cortex: 419 nTPM
  • hippocampal formation: 390 nTPM
  • basal ganglia: 310 nTPM
  • amygdala: 295 nTPM
  • white matter: 279 nTPM
  • cerebellum: 270 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DLG4.

Disease | AllUniProt

Conditions DLG4 is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal dominant 62 (MRD62) MIM:618793

Disease | GeneticClinVar

102 pathogenic / likely-pathogenic of 312 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
4.93
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLG4 as an antibody target. Whether an autoantibody or antibody against DLG4 could matter depends on whether native DLG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLG4 is annotated at the cell surface, where native DLG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLG4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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