Seroatlas · Human Serome Atlas

KTI12

Protein KTI12 homolog

Also known as: KTI12_HUMAN, MGC20419, SBBI81, TOT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EK9
Gene: KTI12
Ensembl: ENSG00000198841
Chromosome: 1
Canonical length: 354 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable ATP binding activity. Predicted to be involved in tRNA wobble uridine modification. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q96EK9|KTI12
     1  MPLVVFCGLP YSGKSRRAEE LRVALAAEGR AVYVVDDAAV LGAEDPAVYG DSAREKALRG
    61  ALRASVERRL SRHDVVILDS LNYIKGFRYE LYCLARAART PLCLVYCVRP GGPIAGPQVA
   121  GANENPGRNV SVSWRPRAEE DGRAQAAGSS VLRELHTADS VVNGSAQADV PKELEREESG
   181  AAESPALVTP DSEKSAKHGS GAFYSPELLE ALTLRFEAPD SRNRWDRPLF TLVGLEEPLP
   241  LAGIRSALFE NRAPPPHQST QSQPLASGSF LHQLDQVTSQ VLAGLMEAQK SAVPGDLLTL
   301  PGTTEHLRFT RPLTMAELSR LRRQFISYTK MHPNNENLPQ LANMFLQYLS QSLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KTI12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
ovary: 10 nTPM
adrenal gland: 9.6 nTPM
lymph node: 8.1 nTPM
spleen: 8.1 nTPM
small intestine: 7.2 nTPM

Single-cell type

thymic myoid cells: 1.4 nCPM
goblet cells: 0.2 nCPM
megakaryocyte-erythroid progenitors: 0.2 nCPM
alveolar cells type 1: 0.1 nCPM
extravillous trophoblasts: 0.1 nCPM
lymphatic endothelial cells: 0.1 nCPM

Immune cell

plasmacytoid DC: 45 nTPM
memory B-cell: 30 nTPM
myeloid DC: 29 nTPM
naive CD4 T-cell: 29 nTPM
memory CD8 T-cell: 27 nTPM
T-reg: 27 nTPM

Brain region

hypothalamus: 7.9 nTPM
choroid plexus: 7.5 nTPM
medulla oblongata: 6.7 nTPM
cerebellum: 6.6 nTPM
white matter: 6.6 nTPM
cerebral cortex: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.5
DepMap mean gene effect: -0.64
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA wobble uridine modification

Molecular functions

ATP binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KTI12 as an antibody target. Whether an autoantibody or antibody against KTI12 could matter depends on whether native KTI12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KTI12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KTI12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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