Seroatlas · Human Serome Atlas

XRCC3

DNA repair protein XRCC3

Also known as: XRCC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43542
Gene
XRCC3
Ensembl
ENSG00000126215
Chromosome
14
Canonical length
346 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>O43542|XRCC3
     1  MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS
    61  SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL
   121  CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF
   181  IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARHLQSLGA
   241  TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR
   301  LREEEAALGC PARTLRVLSA PHLPPSSCSY TISAEGVRGT PGTQSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XRCC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skin: 37 nTPM
  • bone marrow: 30 nTPM
  • spleen: 21 nTPM
  • cerebellum: 16 nTPM
  • lymph node: 14 nTPM
  • testis: 13 nTPM

Single-cell type

  • epicardial cells: 166 nCPM
  • cardiomyocytes: 123 nCPM
  • megakaryocyte progenitors: 39 nCPM
  • erythrocyte progenitors: 38 nCPM
  • differentiating spermatogonia: 20 nCPM
  • megakaryocyte-erythroid progenitors: 19 nCPM

Immune cell

  • total PBMC: 1.3 nTPM
  • memory B-cell: 1.1 nTPM
  • gdT-cell: 1 nTPM
  • MAIT T-cell: 1 nTPM
  • eosinophil: 0.9 nTPM
  • intermediate monocyte: 0.9 nTPM

Brain region

  • medulla oblongata: 41 nTPM
  • white matter: 40 nTPM
  • basal ganglia: 37 nTPM
  • choroid plexus: 37 nTPM
  • cerebral cortex: 33 nTPM
  • thalamus: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about XRCC3.

Disease | AllUniProt

Conditions XRCC3 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
gnomAD missense Z
0.39
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of XRCC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XRCC3 as an antibody target. Whether an autoantibody or antibody against XRCC3 could matter depends on whether native XRCC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XRCC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label XRCC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/XRCC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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