AK5

Protein identityUniProt · HPA

UniProt accession

Q9Y6K8

Gene

AK5

Ensembl

ENSG00000154027

Chromosome

1

Canonical length

562 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q9Y6K8|AK5
     1  MNTNDAKEYL ARREIPQLFE SLLNGLMCSK PEDPVEYLES CLQKVKELGG CDKVKWDTFV
    61  SQEKKTLPPL NGGQSRRSFL RNVMPENSNF PYRRYDRLPP IHQFSIESDT DLSETAELIE
   121  EYEVFDPTRP RPKIILVIGG PGSGKGTQSL KIAERYGFQY ISVGELLRKK IHSTSSNRKW
   181  SLIAKIITTG ELAPQETTIT EIKQKLMQIP DEEGIVIDGF PRDVAQALSF EDQICTPDLV
   241  VFLACANQRL KERLLKRAEQ QGRPDDNVKA TQRRLMNFKQ NAAPLVKYFQ EKGLIMTFDA
   301  DRDEDEVFYD ISMAVDNKLF PNKEAAAGSS DLDPSMILDT GEIIDTGSDY EDQGDDQLNV
   361  FGEDTMGGFM EDLRKCKIIF IIGGPGSGKG TQCEKLVEKY GFTHLSTGEL LREELASESE
   421  RSKLIRDIME RGDLVPSGIV LELLKEAMVA SLGDTRGFLI DGYPREVKQG EEFGRRIGDP
   481  QLVICMDCSA DTMTNRLLQR SRSSLPVDDT TKTIAKRLEA YYRASIPVIA YYETKTQLHK
   541  INAEGTPEDV FLQLCTAIDS IF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

125 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AK5.

Disease | AutoantibodyPubMed

Conditions in which antibodies against AK5 are reported. Each links to that disease's full target list.

• Limbic Encephalitis 3

ReferencesPubMed · IEDB

Publications for AK5 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.56

gnomAD pLI

0

gnomAD missense Z

2.15

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ADP biosynthetic process
• ATP metabolic process
• pyrimidine ribonucleotide biosynthetic process
• dADP biosynthetic process

Molecular functions

• AMP kinase activity
• ATP binding
• nucleoside diphosphate kinase activity

Cellular components

• centriolar satellite
• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Adenylate kinase/UMP-CMP kinase
• Adenylate kinase, isozyme 1/5
• P-loop containing nucleoside triphosphate hydrolase
• Adenylate kinase, conserved site
• Adenylate kinase

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Nucleotide-binding
• Transferase

InteractionsUniProt · HPA

Protein binding partners of AK5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• YWHAZ