Seroatlas · Human Serome Atlas

RIT2

GTP-binding protein Rit2

Also known as: RIBA, RIN, RIT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99578
Gene: RIT2
Ensembl: ENSG00000152214
Chromosome: 18
Canonical length: 217 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>Q99578|RIT2
     1  MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ
    61  VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV
   121  RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE
   181  IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 62 nTPM
basal ganglia: 23 nTPM
hypothalamus: 22 nTPM
cerebral cortex: 20 nTPM
hippocampal formation: 8.9 nTPM
amygdala: 7.2 nTPM

Single-cell type

brain excitatory neurons: 523 nCPM
oligodendrocyte progenitor cells: 303 nCPM
retinal ganglion cells: 232 nCPM
other brain neurons: 191 nCPM
brain inhibitory neurons: 191 nCPM
oocytes: 65 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 46 nTPM
pons: 26 nTPM
cerebral cortex: 20 nTPM
hypothalamus: 18 nTPM
medulla oblongata: 17 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIT2 as an antibody target. Whether an autoantibody or antibody against RIT2 could matter depends on whether native RIT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIT2 is annotated at the cell surface, where native RIT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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