Seroatlas · Human Serome Atlas

ARL10

ADP-ribosylation factor-like protein 10

Also known as: ARL10_HUMAN, ARL10A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8L6
Gene: ARL10
Ensembl: ENSG00000175414
Chromosome: 5
Canonical length: 244 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity and GTPase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q8N8L6|ARL10
     1  MAPRPLGPLV LALGGAAAVL GSVLFILWKT YFGRGRERRW DRGEAWWGAE AARLPEWDEW
    61  DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK PPLEGHIPTW GFNSVRLPTK
   121  DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV FVVDSADRLR LPWARQELHK LLDKDPDLPV
   181  VVVANKQDLS EAMSMGELQR ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL
   241  ELLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skin: 13 nTPM
ovary: 7.3 nTPM
skeletal muscle: 6.3 nTPM
cerebral cortex: 6.2 nTPM
cerebellum: 5.6 nTPM
colon: 5.6 nTPM

Single-cell type

epicardial cells: 207 nCPM
cardiomyocytes: 143 nCPM
myonuclei: 60 nCPM
adipocytes: 43 nCPM
colonocytes: 41 nCPM
fibro-adipogenic progenitors: 34 nCPM

Immune cell

memory B-cell: 1.7 nTPM
NK-cell: 1.4 nTPM
naive B-cell: 1.2 nTPM
memory CD4 T-cell: 1.1 nTPM
memory CD8 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM

Brain region

hypothalamus: 38 nTPM
cerebellum: 34 nTPM
cerebral cortex: 34 nTPM
basal ganglia: 32 nTPM
amygdala: 31 nTPM
hippocampal formation: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Small GTPase superfamily, ARF/SAR type
P-loop containing nucleoside triphosphate hydrolase
ADP-ribosylation factor family
ADP-ribosylation factor-like protein 10

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL10 as an antibody target. Whether an autoantibody or antibody against ARL10 could matter depends on whether native ARL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...