ARL5C
Putative ADP-ribosylation factor-like protein 5C
Also known as: ARL12, ARL5C_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NH57
- Gene
- ARL5C
- Ensembl
- ENSG00000141748
- Chromosome
- 17
- Canonical length
- 179 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>A6NH57|ARL5C
1 MGQLIAKLMS IFGNQEHTVI IVGLDNEGKT TILYRFLTNE VVHMCPTIGS NVEEIILPKT
61 HFFMWDIVRP EALSFIWNTY YSNTEFIILV IDSTDRDRLL TTREELYKML AHEALQDASV
121 LIFANKQDVK DSMRMVEISH FLTLSTIKDH SWHIQGCCAL TREGLPARLQ WMESQAAANLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARL5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 3.2 nTPM
Expression across tissuesHPA
Tissue
- thymus: 3.2 nTPM
- retina: 0.6 nTPM
- pancreas: 0.3 nTPM
- lymph node: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- retinal bipolar cells: 45 nCPM
- pdcs: 22 nCPM
- microglia: 17 nCPM
- thymocytes: 6.8 nCPM
- megakaryocytes: 6.2 nCPM
- macrophages: 4 nCPM
Immune cell
- plasmacytoid DC: 0.4 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- hippocampal formation: 0.2 nTPM
- spinal cord: 0.2 nTPM
- thalamus: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.76
- gnomAD pLI
- 0.31
- gnomAD missense Z
- 0.9
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARL5C as an antibody target. Whether an autoantibody or antibody against ARL5C could matter depends on whether native ARL5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARL5C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARL5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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