Seroatlas · Human Serome Atlas

GIMAP4

GTPase IMAP family member 4

Also known as: FLJ11110, GIMA4_HUMAN, HIMAP4, IAN1, IMAP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUV9
Gene: GIMAP4
Ensembl: ENSG00000133574
Chromosome: 7
Canonical length: 329 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9NUV9|GIMAP4
     1  MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI LGRKVFHSGT
    61  AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS KEIIRCILLT SPGPHALLLV
   121  VPLGRYTEEE HKATEKILKM FGERARSFMI LIFTRKDDLG DTNLHDYLRE APEDIQDLMD
   181  IFGDRYCALN NKATGAEQEA QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM
   241  QELHRVELER EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE
   301  VESKDGILEL IMTALQIASF ILLRLFAED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

lymph node: 120 nTPM
spleen: 109 nTPM
tonsil: 80 nTPM
appendix: 71 nTPM
lung: 48 nTPM
placenta: 46 nTPM

Single-cell type

kupffer cells: 277 nCPM
vascular endothelial cells: 202 nCPM
lymphatic endothelial cells: 174 nCPM
hofbauer cells: 143 nCPM
t-cells: 128 nCPM
neutrophils: 113 nCPM

Immune cell

total PBMC: 776 nTPM
naive CD4 T-cell: 425 nTPM
memory CD4 T-cell: 409 nTPM
MAIT T-cell: 405 nTPM
memory CD8 T-cell: 403 nTPM
intermediate monocyte: 391 nTPM

Brain region

medulla oblongata: 19 nTPM
spinal cord: 18 nTPM
white matter: 17 nTPM
pons: 16 nTPM
thalamus: 13 nTPM
choroid plexus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GIMAP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP4 as an antibody target. Whether an autoantibody or antibody against GIMAP4 could matter depends on whether native GIMAP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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