HS3ST4
Heparan sulfate glucosamine 3-O-sulfotransferase 4
Also known as: 3OST4, HS3S4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y661
- Gene
- HS3ST4
- Ensembl
- ENSG00000182601
- Chromosome
- 16
- Canonical length
- 456 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
456 residues, UniProt reviewed canonical sequence.
>Q9Y661|HS3ST4
1 MARWPAPPPP PPPPPPLAAP PPPGASAKGP PARKLLFMCT LSLSVTYLCY SLLGGSGSLQ
61 FPLALQESPG AAAEPPPSPP PPSLLPTPVR LGAPSQPPAP PPLDNASHGE PPEPPEQPAA
121 PGTDGWGLPS GGGGAQDAWL RTPLAPSEMI TAQSALPERE AQESSTTDED LAGRRAANGS
181 SERGGAVSTP DYGEKKLPQA LIIGVKKGGT RALLEAIRVH PDVRAVGVEP HFFDRNYEKG
241 LEWYRNVMPK TLDGQITMEK TPSYFVTNEA PKRIHSMAKD IKLIVVVRNP VTRAISDYTQ
301 TLSKKPEIPT FEVLAFKNRT LGLIDASWSA IRIGIYALHL ENWLQYFPLS QILFVSGERL
361 IVDPAGEMAK VQDFLGLKRV VTEKHFYFNK TKGFPCLKKP EDSSAPRCLG KSKGRTHPRI
421 DPDVIHRLRK FYKPFNLMFY QMTGQDFQWE QEEGDKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HS3ST4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 17 nTPM
- hippocampal formation: 11 nTPM
- basal ganglia: 9.7 nTPM
- hypothalamus: 9.7 nTPM
- amygdala: 7.9 nTPM
- cerebellum: 7.9 nTPM
Single-cell type
- microglia: 1,018 nCPM
- retinal bipolar cells: 295 nCPM
- brain excitatory neurons: 112 nCPM
- other brain neurons: 91 nCPM
- brain inhibitory neurons: 60 nCPM
- undifferentiated spermatogonia: 47 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 74 nTPM
- cerebral cortex: 62 nTPM
- pons: 34 nTPM
- basal ganglia: 33 nTPM
- white matter: 31 nTPM
- hippocampal formation: 22 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.49
- gnomAD pLI
- 0.8
- gnomAD missense Z
- 0.87
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HS3ST4 as an antibody target. Whether an autoantibody or antibody against HS3ST4 could matter depends on whether native HS3ST4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HS3ST4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HS3ST4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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