Seroatlas · Human Serome Atlas

ABCC4

ATP-binding cassette sub-family C member 4

Also known as: EST170205, MOAT-B, MOATB, MRP4, MRP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15439
Gene: ABCC4
Ensembl: ENSG00000125257
Chromosome: 13
Canonical length: 1325 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

1325 residues, UniProt reviewed canonical sequence.

>O15439|ABCC4
     1  MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL
    61  QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF
   121  ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR
   181  LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG
   241  MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT
   301  NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA
   361  VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD
   421  KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ
   481  QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK
   541  ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA
   601  SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW
   661  SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKNYFRAGAH WIVFIFLILL
   721  NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTEKLD LNWYLGIYSG LTVATVLFGI
   781  ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF
   841  LDFIQTLLQV VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV
   901  FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAMFV
   961  IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS AEVENMMISV ERVIEYTDLE
  1021  KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY SPGGPLVLKH LTALIKSQEK VGIVGRTGAG
  1081  KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE
  1141  HTDEELWNAL QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII
  1201  DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG RLKEYDEPYV
  1261  LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI GHTDHMVTNT SNGQPSTLTI
  1321  FETAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

prostate: 39 nTPM
parathyroid gland: 21 nTPM
epididymis: 18 nTPM
kidney: 17 nTPM
urinary bladder: 14 nTPM
fallopian tube: 9.6 nTPM

Single-cell type

renal collecting duct intercalated cells: 1,141 nCPM
microglia: 944 nCPM
megakaryocyte-erythroid progenitors: 529 nCPM
platelets: 444 nCPM
mast cells: 410 nCPM
megakaryocyte progenitors: 381 nCPM

Immune cell

non-classical monocyte: 2.3 nTPM
NK-cell: 2 nTPM
myeloid DC: 1.8 nTPM
naive B-cell: 1.6 nTPM
memory CD8 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.5 nTPM

Brain region

choroid plexus: 17 nTPM
hypothalamus: 13 nTPM
white matter: 12 nTPM
spinal cord: 12 nTPM
medulla oblongata: 11 nTPM
midbrain: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 1.7
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

ABC transporter-like, ATP-binding domain
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase
ABC transporter type 1, transmembrane domain superfamily
ATP-binding cassette transporter C-like
ABC transporter
ABC transporter transmembrane region
ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 1
ATP-binding cassette sub-family C member 4, six-transmembrane helical domain 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABCC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MPP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABCC4 as an antibody target. Whether an autoantibody or antibody against ABCC4 could matter depends on whether native ABCC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABCC4 is annotated at the cell surface, where native ABCC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABCC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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