Seroatlas · Human Serome Atlas

ABCF2

ATP-binding cassette sub-family F member 2

Also known as: ABC28, ABCF2_HUMAN, EST133090, HUSSY-18, M-ABC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UG63
Gene
ABCF2
Ensembl
ENSG00000033050
Chromosome
7
Canonical length
623 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, Mar 2019]

Canonical amino-acid sequenceUniProt

623 residues, UniProt reviewed canonical sequence.

>Q9UG63|ABCF2
     1  MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET TEVDLLTKEL
    61  EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL LSDTKLELNS GRRYGLIGLN
   121  GIGKSMLLSA IGKREVPIPE HIDIYHLTRE MPPSDKTPLH CVMEVDTERA MLEKEAERLA
   181  HEDAECEKLM ELYERLEELD ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA
   241  RALFIRPFML LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN
   301  KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA KLARQAQSKE
   361  KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN VSFKYTKDGP CIYNNLEFGI
   421  DLDTRVALVG PNGAGKSTLL KLLTGELLPT DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL
   481  EYMMKCYPEI KEKEEMRKII GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL
   541  DEPTNHLDIE TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA
   601  YKEHLKSKLV DEEPQLTKRT HNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 38 nTPM
  • tongue: 19 nTPM
  • heart muscle: 19 nTPM
  • cerebral cortex: 19 nTPM
  • testis: 15 nTPM
  • cerebellum: 14 nTPM

Single-cell type

  • other brain neurons: 16 nCPM
  • brain excitatory neurons: 15 nCPM
  • brain inhibitory neurons: 15 nCPM
  • oligodendrocytes: 11 nCPM
  • astrocytes: 10 nCPM
  • oligodendrocyte progenitor cells: 9.5 nCPM

Immune cell

  • MAIT T-cell: 20 nTPM
  • T-reg: 16 nTPM
  • non-classical monocyte: 15 nTPM
  • total PBMC: 15 nTPM
  • NK-cell: 15 nTPM
  • memory CD4 T-cell: 14 nTPM

Brain region

  • cerebral cortex: 30 nTPM
  • medulla oblongata: 28 nTPM
  • pons: 26 nTPM
  • midbrain: 25 nTPM
  • hypothalamus: 25 nTPM
  • white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.01
gnomAD missense Z
2.48

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABCF2 as an antibody target. Whether an autoantibody or antibody against ABCF2 could matter depends on whether native ABCF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABCF2 is annotated at the cell surface, where native ABCF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABCF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABCF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...