Seroatlas · Human Serome Atlas

RAB33B

Ras-related protein Rab-33B

Also known as: DKFZP434G099, RB33B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H082
Gene
RAB33B
Ensembl
ENSG00000172007
Chromosome
4
Canonical length
229 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q9H082|RAB33B
     1  MAEEMESSLE ASFSSSGAVS GASGFLPPAR SRIFKIIVIG DSNVGKTCLT YRFCAGRFPD
    61  RTEATIGVDF RERAVEIDGE RIKIQLWDTA GQERFRKSMV QHYYRNVHAV VFVYDMTNMA
   121  SFHSLPSWIE ECKQHLLAND IPRILVGNKC DLRSAIQVPT DLAQKFADTH SMPLFETSAK
   181  NPNDNDHVEA IFMTLAHKLK SHKPLMLSQP PDNGIILKPE PKPAMTCWC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB33B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • liver: 16 nTPM
  • bone marrow: 12 nTPM
  • pancreas: 9.5 nTPM
  • endometrium: 8.8 nTPM
  • placenta: 8.5 nTPM
  • ovary: 8.4 nTPM

Single-cell type

  • neutrophils: 107 nCPM
  • late spermatids: 94 nCPM
  • cardiomyocytes: 89 nCPM
  • epicardial cells: 68 nCPM
  • neutrophil progenitors: 65 nCPM
  • early spermatids: 42 nCPM

Immune cell

  • neutrophil: 23 nTPM
  • eosinophil: 8.8 nTPM
  • MAIT T-cell: 5.8 nTPM
  • naive CD4 T-cell: 5.6 nTPM
  • T-reg: 5.2 nTPM
  • naive CD8 T-cell: 5.1 nTPM

Brain region

  • white matter: 17 nTPM
  • cerebellum: 17 nTPM
  • medulla oblongata: 15 nTPM
  • pons: 13 nTPM
  • thalamus: 13 nTPM
  • spinal cord: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB33B.

Disease | AllUniProt

Conditions RAB33B is implicated in, by any mechanism.

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 139 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Smith-McCort dysplasia 2
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.68
gnomAD missense Z
0.63
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB33B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB33B as an antibody target. Whether an autoantibody or antibody against RAB33B could matter depends on whether native RAB33B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB33B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB33B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB33B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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