DDX51
ATP-dependent RNA helicase DDX51
Also known as: DDX51_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8A6
- Gene
- DDX51
- Ensembl
- ENSG00000185163
- Chromosome
- 12
- Canonical length
- 666 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Cytosol
OverviewNCBI Gene
Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
666 residues, UniProt reviewed canonical sequence.
>Q8N8A6|DDX51
1 MALFYVARYP GPDAAAAAGP EGAEAGAHGR ARALLERLQS RARERQQQRE PAQTEAAAST
61 EPATRRRRRP RRRRRVNDAE PGSPEAPQGK RRKADGEDAG AESNEEAPGE PSAGSSEEAP
121 GEPSAGSSEE APGERSTSAS AEAAPDGPAL EEAAGPLVPG LVLGGFGKRK APKVQPFLPR
181 WLAEPNCVRR NVTEDLVPIE DIPDVHPDLQ KQLRAHGISS YFPVQAAVIP ALLESAACGF
241 LVGRGGYRPS DLCVSAPTGS GKTLAFVIPV VQALLSRVVC HIRALVVLPT KELAQQVSKV
301 FNIYTDATPL RVSLVTGQKS LAKEQESLVQ KTADGYRCLA DIVVATPGRL VDHIDQTPGF
361 SLQQLRFLII DEADRMIDSM HQSWLPRVVA AAFQSEDPAD PCALLQRRQA QAVTAASTCC
421 PQMPLQKLLF SATLTQNPEK LQQLGLHQPR LFSTGLAHRG LEDTDGDGDS GKYAFPVGLT
481 HHYVPCSLSS KPLVVLHLVL EMGFSRVLCF TNSRENSHRL FLLVQAFGGV DVAEFSSRYG
541 PGQRRMILKQ FEQGKIQLLI STDATARGID VQGVELVVNY DAPQYLRTYV HRVGRTARAG
601 KTGQAFTLLL KVQERRFLRM LTEAGAPELQ RHELSSKLLQ PLVPRYEEAL SQLEESVKEE
661 RKQRAALocalizationUniProt · AlphaFold · HPA
Whether an antibody against DDX51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 19 nTPM
- cerebral cortex: 15 nTPM
- ovary: 13 nTPM
- skin: 12 nTPM
- pancreas: 11 nTPM
- basal ganglia: 9.5 nTPM
Single-cell type
- brain inhibitory neurons: 20 nCPM
- brain excitatory neurons: 20 nCPM
- oligodendrocytes: 13 nCPM
- other brain neurons: 12 nCPM
- renal connecting tubule cells: 11 nCPM
- astrocytes: 11 nCPM
Immune cell
- naive B-cell: 0.2 nTPM
- neutrophil: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0.1 nTPM
- eosinophil: 0.1 nTPM
Brain region
- cerebral cortex: 8.5 nTPM
- white matter: 6.9 nTPM
- pons: 6.1 nTPM
- basal ganglia: 6 nTPM
- hippocampal formation: 6 nTPM
- medulla oblongata: 5.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.41
- DepMap mean gene effect
- -0.9
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DDX51 as an antibody target. Whether an autoantibody or antibody against DDX51 could matter depends on whether native DDX51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DDX51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DDX51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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