Seroatlas · Human Serome Atlas

WRNIP1

ATPase WRNIP1

Also known as: bA420G6.2, CFAP93, FAP93, FLJ22526, WHIP, WRIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96S55
Gene
WRNIP1
Ensembl
ENSG00000124535
Chromosome
6
Canonical length
665 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homooligomer

OverviewNCBI Gene

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q96S55|WRNIP1
     1  MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP AAGSHRAGER
    61  AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD DGGETESRES YDAPPTPSGA
   121  RLIPDFPVAR SSSPGRKGSG KRPAAAAAAG SASPRSWDEA EAQEEEEAVG DGDGDGDADA
   181  DGEDDPGHWD ADAAEAATAF GASGGGRPHP RALAAEEIRQ MLQGKPLADT MRPDTLQDYF
   241  GQSKAVGQDT LLRSLLETNE IPSLILWGPP GCGKTTLAHI IASNSKKHSI RFVTLSATNA
   301  KTNDVRDVIK QAQNEKSFFK RKTILFIDEI HRFNKSQQDT FLPHVECGTI TLIGATTENP
   361  SFQVNAALLS RCRVIVLEKL PVEAMVTILM RAINSLGIHV LDSSRPTDPL SHSSNSSSEP
   421  AMFIEDKAVD TLAYLSDGDA RAGLNGLQLA VLARLSSRKM FCKKSGQSYS PSRVLITEND
   481  VKEGLQRSHI LYDRAGEEHY NCISALHKSM RGSDQNASLY WLARMLEGGE DPLYVARRLV
   541  RFASEDIGLA DPSALTQAVA AYQGCHFIGM PECEVLLAQC VVYFARAPKS IEVYSAYNNV
   601  KACLRNHQGP LPPVPLHLRN APTRLMKDLG YGKGYKYNPM YSEPVDQEYL PEELRGVDFF
   661  KQRRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WRNIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 71 nTPM
  • cerebellum: 55 nTPM
  • esophagus: 47 nTPM
  • bone marrow: 46 nTPM
  • choroid plexus: 44 nTPM
  • parathyroid gland: 44 nTPM

Single-cell type

  • platelets: 190 nCPM
  • megakaryocyte progenitors: 111 nCPM
  • hematopoietic stem cells: 105 nCPM
  • megakaryocytes: 105 nCPM
  • early spermatids: 74 nCPM
  • gastric progenitor cells: 72 nCPM

Immune cell

  • basophil: 9.3 nTPM
  • T-reg: 4.2 nTPM
  • gdT-cell: 4 nTPM
  • naive CD4 T-cell: 3.1 nTPM
  • naive CD8 T-cell: 3 nTPM
  • memory CD8 T-cell: 2.8 nTPM

Brain region

  • hippocampal formation: 44 nTPM
  • cerebellum: 43 nTPM
  • hypothalamus: 43 nTPM
  • basal ganglia: 41 nTPM
  • cerebral cortex: 41 nTPM
  • choroid plexus: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.02
gnomAD missense Z
-1.09
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WRNIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WRNIP1 as an antibody target. Whether an autoantibody or antibody against WRNIP1 could matter depends on whether native WRNIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WRNIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WRNIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WRNIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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