NVL

Protein identityUniProt · HPA

UniProt accession

O15381

Gene

NVL

Ensembl

ENSG00000143748

Chromosome

1

Canonical length

856 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli

OverviewNCBI Gene

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

856 residues, UniProt reviewed canonical sequence.

>O15381|NVL
     1  MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR KRNAFRIQVE
    61  KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY SDDDSSMEDY PDPQSANHMN
   121  SSLLSLYRKG NPDSVSNTPE MEQRETTSST PRISSKTGSI PLKTPAKDSE GGWFIDKTPS
   181  VKKDSFFLDL SCEKSNPKKP ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG
   241  EIEAVLQKKA KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG
   301  VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF EQAVSNAPCI
   361  IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA TARVLVIGAT NRPDSLDPAL
   421  RRAGRFDREI CLGIPDEASR ERILQTLCRK LRLPQAFDFC HLAHLTPGFV GADLMALCRE
   481  AAMCAVNRVL MKLQEQQKKN PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP
   541  LSEEQMQGLC IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP
   601  VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE LLNMYVGESE
   661  RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR VVNQLLTEMD GLEARQQVFI
   721  MAATNRPDII DPAILRPGRL DKTLFVGLPP PADRLAILKT ITKNGTKPPL DADVNLEAIA
   781  GDLRCDCYTG ADLSALVREA SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS
   841  KKDQIMYERL QESLSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NVL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NVL.

Disease | AutoantibodyPubMed

Conditions in which antibodies against NVL are reported. Each links to that disease's full target list.

• Scleroderma, Systemic 3

ReferencesPubMed · IEDB

Publications for NVL from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

1.59

DepMap mean gene effect

-1.29

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of protein binding
• positive regulation of telomere maintenance
• regulation of protein localization to nucleolus
• ribosomal large subunit biogenesis
• ribosome biogenesis
• rRNA processing
• telomerase holoenzyme complex assembly

Molecular functions

• ATP binding
• ATP hydrolysis activity
• preribosome binding
• RNA binding

Cellular components

• membrane
• nucleolus
• nucleoplasm
• nucleus
• telomerase holoenzyme complex

Protein domainsUniProt · Pfam · InterPro

• AAA+ ATPase domain
• ATPase, AAA-type, core
• ATPase, AAA-type, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• AAA ATPase, AAA+ lid domain
• AAA ATPase domain-containing protein
• ATPase family associated with various cellular activities (AAA)
• AAA+ lid domain
• NVL2, nucleolin binding domain
• NVL2, N-terminal domain superfamily
• Nucleolin binding domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Isopeptide bond
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repeat
• Ribosome biogenesis
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of NVL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MTREX
• RPL5
• WDR74
• NCL