Seroatlas · Human Serome Atlas

SEPTIN12

Septin-12

Also known as: FLJ25410, SEP12_HUMAN, SEPT12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYM1
Gene
SEPTIN12
Ensembl
ENSG00000140623
Chromosome
16
Canonical length
358 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Annulus

OverviewNCBI Gene

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q8IYM1|SEPTIN12
     1  MDPLRRSPSP CLSSQPSSPS TPPCEMLGPV GIEAVLDQLK IKAMKMGFEF NIMVVGQSGL
    61  GKSTMVNTLF KSKVWKSNPP GLGVPTPQTL QLHSLTHVIE EKGVKLKLTV TDTPGFGDQI
   121  NNDNCWDPIL GYINEQYEQY LQEEILITRQ RHIPDTRVHC CVYFVPPTGH CLRPLDIEFL
   181  QRLCRTVNVV PVIARADSLT MEEREAFRRR IQQNLRTHCI DVYPQMCFDE DINDKILNSK
   241  LRDRIPFAVV GADQEHLVNG RCVLGRKTKW GIIEVENMAH CEFPLLRDLL IRSHLQDLKD
   301  ITHNIHYENY RVIRLNESHL LPRGPGWVNL APASPGQLTT PRTFKVCRGA HDDSDDEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • testis: 104 nTPM
  • cerebellum: 2.8 nTPM
  • spinal cord: 0.8 nTPM
  • hippocampal formation: 0.5 nTPM
  • retina: 0.5 nTPM
  • midbrain: 0.4 nTPM

Single-cell type

  • late primary spermatocytes: 468 nCPM
  • early spermatids: 316 nCPM
  • late spermatids: 155 nCPM
  • early primary spermatocytes: 19 nCPM
  • sertoli cells: 3.4 nCPM
  • oligodendrocytes: 2.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.7 nTPM
  • cerebral cortex: 1.4 nTPM
  • pons: 1.4 nTPM
  • white matter: 1.2 nTPM
  • basal ganglia: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEPTIN12.

Disease | AllUniProt

Conditions SEPTIN12 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN12 as an antibody target. Whether an autoantibody or antibody against SEPTIN12 could matter depends on whether native SEPTIN12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEPTIN12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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