Seroatlas · Human Serome Atlas

KATNAL1

Katanin p60 ATPase-containing subunit A-like 1

Also known as: KATL1_HUMAN, MGC2599

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BW62
Gene
KATNAL1
Ensembl
ENSG00000102781
Chromosome
13
Canonical length
490 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Mitotic spindle,Centrosome,Mitochondria,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity and microtubule severing ATPase activity. Involved in microtubule severing. Located in cytosol; microtubule cytoskeleton; and mitochondrion. Part of katanin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q9BW62|KATNAL1
     1  MNLAEICDNA KKGREYALLG NYDSSMVYYQ GVMQQIQRHC QSVRDPAIKG KWQQVRQELL
    61  EEYEQVKSIV STLESFKIDK PPDFPVSCQD EPFRDPAVWP PPVPAEHRAP PQIRRPNREV
   121  RPLRKEMAGV GARGPVGRAH PISKSEKPST SRDKDYRARG RDDKGRKNMQ DGASDGEMPK
   181  FDGAGYDKDL VEALERDIVS RNPSIHWDDI ADLEEAKKLL REAVVLPMWM PDFFKGIRRP
   241  WKGVLMVGPP GTGKTMLAKA VATECGTTFF NVSSSTLTSK YRGESEKLVR LLFEMARFYA
   301  PTTIFIDEID SICSRRGTSD EHEASRRVKS ELLIQMDGVG GALENDDPSK MVMVLAATNF
   361  PWDIDEALRR RLEKRIYIPL PTAKGRAELL KINLREVELD PDIQLEDIAE KIEGYSGADI
   421  TNVCRDASLM AMRRRINGLS PEEIRALSKE ELQMPVTKGD FELALKKIAK SVSAADLEKY
   481  EKWMVEFGSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KATNAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • heart muscle: 17 nTPM
  • smooth muscle: 14 nTPM
  • cerebral cortex: 9.3 nTPM
  • cervix: 9.1 nTPM
  • endometrium: 8.7 nTPM

Single-cell type

  • early spermatids: 220 nCPM
  • late primary spermatocytes: 156 nCPM
  • ependymal cells: 153 nCPM
  • fibro-adipogenic progenitors: 130 nCPM
  • adipocytes: 115 nCPM
  • podocytes: 111 nCPM

Immune cell

  • NK-cell: 7.7 nTPM
  • T-reg: 5.9 nTPM
  • plasmacytoid DC: 5.5 nTPM
  • naive B-cell: 4.5 nTPM
  • gdT-cell: 4.4 nTPM
  • memory CD8 T-cell: 4.4 nTPM

Brain region

  • white matter: 46 nTPM
  • cerebral cortex: 41 nTPM
  • thalamus: 41 nTPM
  • hypothalamus: 40 nTPM
  • basal ganglia: 40 nTPM
  • spinal cord: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.53
gnomAD missense Z
1.6
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KATNAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KATNAL1 as an antibody target. Whether an autoantibody or antibody against KATNAL1 could matter depends on whether native KATNAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KATNAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KATNAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KATNAL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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