Seroatlas · Human Serome Atlas

MYH15

Myosin-15

Also known as: KIAA1000, MYH15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2K3
Gene: MYH15
Ensembl: ENSG00000144821
Chromosome: 3
Canonical length: 1926 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in extraocular skeletal muscle development. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1926 residues, UniProt reviewed canonical sequence.

>Q9Y2K3|MYH15
     1  MDLSDLGEAA AFLRRSEAEL LLLQATALDG KKKCWIPDGE NAYIEAEVKG SEDDGTVIVE
    61  TADGESLSIK EDKIQQMNPP EFEMIEDMAM LTHLNEASVL HTLKRRYGQW MIYTYSGLFC
   121  VTINPYKWLP VYQKEVMAAY KGKRRSEAPP HIFAVANNAF QDMLHNRENQ SILFTGESGA
   181  GKTVNSKHII QYFATIAAMI ESRKKQGALE DQIMQANTIL EAFGNAKTLR NDNSSRFGKF
   241  IRMHFGARGM LSSVDIDIYL LEKSRVIFQQ AGERNYHIFY QILSGQKELH DLLLVSANPS
   301  DFHFCSCGAV TVESLDDAEE LLATEQAMDI LGFLPDEKYG CYKLTGAIMH FGNMKFKQKP
   361  REEQLEADGT ENADKAAFLM GINSSELVKC LIHPRIKVGN EYVTRGQTIE QVTCAVGALS
   421  KSMYERMFKW LVARINRALD AKLSRQFFIG ILDITGFEIL EYNSLEQLCI NFTNEKLQQF
   481  FNWHMFVLEQ EEYKKESIEW VSIGFGLDLQ ACIDLIEKPM GILSILEEEC MFPKATDLTF
   541  KTKLFDNHFG KSVHLQKPKP DKKKFEAHFE LVHYAGVVPY NISGWLEKNK DLLNETVVAV
   601  FQKSSNRLLA SLFENYMSTD SAIPFGEKKR KKGASFQTVA SLHKENLNKL MTNLKSTAPH
   661  FVRCINPNVN KIPGILDPYL VLQQLRCNGV LEGTRICREG FPNRLQYADF KQRYCILNPR
   721  TFPKSKFVSS RKAAEELLGS LEIDHTQYRF GITKVFFKAG FLGQLEAIRD ERLSKVFTLF
   781  QARAQGKLMR IKFQKILEER DALILIQWNI RAFMAVKNWP WMRLFFKIKP LVKSSEVGEE
   841  VAGLKEECAQ LQKALEKSEF QREELKAKQV SLTQEKNDLI LQLQAEQETL ANVEEQCEWL
   901  IKSKIQLEAR VKELSERVEE EEEINSELTA RGRKLEDECF ELKKEIDDLE TMLVKSEKEK
   961  RTTEHKVKNL TEEVEFLNED ISKLNRAAKV VQEAHQQTLD DLHMEEEKLS SLSKANLKLE
  1021  QQVDELEGAL EQERKARMNC ERELHKLEGN LKLNRESMEN LESSQRHLAE ELRKKELELS
  1081  QMNSKVENEK GLVAQLQKTV KELQTQIKDL KEKLEAERTT RAKMERERAD LTQDLADLNE
  1141  RLEEVGGSSL AQLEITKKQE TKFQKLHRDM EEATLHFETT SASLKKRHAD SLAELEGQVE
  1201  NLQQVKQKLE KDKSDLQLEV DDLLTRVEQM TRAKANAEKL CTLYEERLHE ATAKLDKVTQ
  1261  LANDLAAQKT KLWSESGEFL RRLEEKEALI NQLSREKSNF TRQIEDLRGQ LEKETKSQSA
  1321  LAHALQKAQR DCDLLREQYE EEQEVKAELH RTLSKVNAEM VQWRMKYENN VIQRTEDLED
  1381  AKKELAIRLQ EAAEAMGVAN ARNASLERAR HQLQLELGDA LSDLGKVRSA AARLDQKQLQ
  1441  SGKALADWKQ KHEESQALLD ASQKEVQALS TELLKLKNTY EESIVGQETL RRENKNLQEE
  1501  ISNLTNQVRE GTKNLTEMEK VKKLIEEEKT EVQVTLEETE GALERNESKI LHFQLELLEA
  1561  KAELERKLSE KDEEIENFRR KQQCTIDSLQ SSLDSEAKSR IEVTRLKKKM EEDLNEMELQ
  1621  LSCANRQVSE ATKSLGQLQI QIKDLQMQLD DSTQLNSDLK EQVAVAERRN SLLQSELEDL
  1681  RSLQEQTERG RRLSEEELLE ATERINLFYT QNTSLLSQKK KLEADVARMQ KEAEEVVQEC
  1741  QNAEEKAKKA AIEAANLSEE LKKKQDTIAH LERTRENMEQ TITDLQKRLA EAEQMALMGS
  1801  RKQIQKLESR VRELEGELEG EIRRSAEAQR GARRLERCIK ELTYQAEEDK KNLSRMQTQM
  1861  DKLQLKVQNY KQQVEVAETQ ANQYLSKYKK QQHELNEVKE RAEVAESQVN KLKIKAREFG
  1921  KKVQEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYH15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 3 nTPM

Expression across tissuesHPA

Tissue

retina: 3 nTPM
tongue: 1.9 nTPM
cerebral cortex: 1.2 nTPM
small intestine: 0.6 nTPM
colon: 0.4 nTPM
duodenum: 0.4 nTPM

Single-cell type

adrenal medulla cells: 43 nCPM
bergmann glia: 38 nCPM
astrocytes: 27 nCPM
müller glia: 19 nCPM
cone photoreceptor cells: 17 nCPM
rod photoreceptor cells: 15 nCPM

Immune cell

naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

basal ganglia: 3.8 nTPM
medulla oblongata: 3.4 nTPM
hypothalamus: 3.3 nTPM
thalamus: 3.2 nTPM
white matter: 3 nTPM
amygdala: 2.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYH15.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 363 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

extraocular skeletal muscle development

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYH15 as an antibody target. Whether an autoantibody or antibody against MYH15 could matter depends on whether native MYH15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYH15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYH15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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