Seroatlas · Human Serome Atlas

KIF22

Kinesin-like protein KIF22

Also known as: Kid, KIF22_HUMAN, KNSL4, OBP-1, OBP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14807
Gene
KIF22
Ensembl
ENSG00000079616
Chromosome
16
Canonical length
665 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q14807|KIF22
     1  MAAGGSTQQR RREMAAASAA AISGAGRCRL SKIGATRRPP PARVRVAVRL RPFVDGTAGA
    61  SDPPCVRGMD SCSLEIANWR NHQETLKYQF DAFYGERSTQ QDIYAGSVQP ILRHLLEGQN
   121  ASVLAYGPTG AGKTHTMLGS PEQPGVIPRA LMDLLQLTRE EGAEGRPWAL SVTMSYLEIY
   181  QEKVLDLLDP ASGDLVIRED CRGNILIPGL SQKPISSFAD FERHFLPASR NRTVGATRLN
   241  QRSSRSHAVL LVKVDQRERL APFRQREGKL YLIDLAGSED NRRTGNKGLR LKESGAINTS
   301  LFVLGKVVDA LNQGLPRVPY RDSKLTRLLQ DSLGGSAHSI LIANIAPERR FYLDTVSALN
   361  FAARSKEVIN RPFTNESLQP HALGPVKLSQ KELLGPPEAK RARGPEEEEI GSPEPMAAPA
   421  SASQKLSPLQ KLSSMDPAML ERLLSLDRLL ASQGSQGAPL LSTPKRERMV LMKTVEEKDL
   481  EIERLKTKQK ELEAKMLAQK AEEKENHCPT MLRPLSHRTV TGAKPLKKAV VMPLQLIQEQ
   541  AASPNAEIHI LKNKGRKRKL ESLDALEPEE KAEDCWELQI SPELLAHGRQ KILDLLNEGS
   601  ARDLRSLQRI GPKKAQLIVG WRELHGPFSQ VEDLERVEGI TGKQMESFLK ANILGLAAGQ
   661  RCGAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 54 nTPM
  • bone marrow: 43 nTPM
  • tonsil: 24 nTPM
  • skin: 22 nTPM
  • parathyroid gland: 21 nTPM
  • lymph node: 21 nTPM

Single-cell type

  • hepatocytes: 683 nCPM
  • monocyte progenitors: 120 nCPM
  • syncytiotrophoblasts: 110 nCPM
  • extravillous trophoblasts: 107 nCPM
  • cytotrophoblasts: 100 nCPM
  • oocytes: 97 nCPM

Immune cell

  • basophil: 54 nTPM
  • T-reg: 48 nTPM
  • memory CD8 T-cell: 47 nTPM
  • memory CD4 T-cell: 43 nTPM
  • gdT-cell: 40 nTPM
  • total PBMC: 34 nTPM

Brain region

  • amygdala: 7.6 nTPM
  • basal ganglia: 7.4 nTPM
  • spinal cord: 7 nTPM
  • thalamus: 6.7 nTPM
  • white matter: 6.6 nTPM
  • hippocampal formation: 6.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF22.

Disease | AllUniProt

Conditions KIF22 is implicated in, by any mechanism.

  • Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2) MIM:603546

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 465 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
0.14
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF22 as an antibody target. Whether an autoantibody or antibody against KIF22 could matter depends on whether native KIF22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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