Seroatlas · Human Serome Atlas

CHST7

Carbohydrate sulfotransferase 7

Also known as: C6ST-2, C6ST2, CHST7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS84
Gene: CHST7
Ensembl: ENSG00000147119
Chromosome: X
Canonical length: 486 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q9NS84|CHST7
     1  MKGRRRRRRE YCKFALLLVL YTLVLLLVPS VLDGGRDGDK GAEHCPGLQR SLGVWSLEAA
    61  AAGEREQGAE ARAAEEGGAN QSPRFPSNLS GAVGEAVSRE KQHIYVHATW RTGSSFLGEL
   121  FNQHPDVFYL YEPMWHLWQA LYPGDAESLQ GALRDMLRSL FRCDFSVLRL YAPPGDPAAR
   181  APDTANLTTA ALFRWRTNKV ICSPPLCPGA PRARAEVGLV EDTACERSCP PVAIRALEAE
   241  CRKYPVVVIK DVRLLDLGVL VPLLRDPGLN LKVVQLFRDP RAVHNSRLKS RQGLLRESIQ
   301  VLRTRQRGDR FHRVLLAHGV GARPGGQSRA LPAAPRADFF LTGALEVICE AWLRDLLFAR
   361  GAPAWLRRRY LRLRYEDLVR QPRAQLRRLL RFSGLRALAA LDAFALNMTR GAAYGADRPF
   421  HLSARDAREA VHAWRERLSR EQVRQVEAAC APAMRLLAYP RSGEEGDAEQ PREGETPLEM
   481  DADGAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

ovary: 32 nTPM
heart muscle: 16 nTPM
adipose tissue: 12 nTPM
cerebral cortex: 9.9 nTPM
spleen: 9.3 nTPM
blood vessel: 9.1 nTPM

Single-cell type

myosatellite cells: 59 nCPM
peritubular myoid cells: 58 nCPM
ovarian stromal cells: 58 nCPM
monocytes: 47 nCPM
decidual stromal cells: 42 nCPM
cardiomyocytes: 41 nCPM

Immune cell

T-reg: 19 nTPM
neutrophil: 11 nTPM
non-classical monocyte: 10 nTPM
intermediate monocyte: 7.1 nTPM
memory CD4 T-cell: 5.8 nTPM
memory CD8 T-cell: 2.8 nTPM

Brain region

thalamus: 15 nTPM
midbrain: 13 nTPM
basal ganglia: 13 nTPM
hypothalamus: 13 nTPM
cerebral cortex: 12 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.07
gnomAD missense Z: 1.94
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST7 as an antibody target. Whether an autoantibody or antibody against CHST7 could matter depends on whether native CHST7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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