Seroatlas · Human Serome Atlas

MCM9

DNA helicase MCM9

Also known as: C6orf61, dJ329L24.3, FLJ20170, MCM9_HUMAN, MCMDC1, MGC35304

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXL9
Gene: MCM9
Ensembl: ENSG00000111877
Chromosome: 6
Canonical length: 1143 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

1143 residues, UniProt reviewed canonical sequence.

>Q9NXL9|MCM9
     1  MNSDQVTLVG QVFESYVSEY HKNDILLILK ERDEDAHYPV VVNAMTLFET NMEIGEYFNM
    61  FPSEVLTIFD SALRRSALTI LQSLSQPEAV SMKQNLHARI SGLPVCPELV REHIPKTKDV
   121  GHFLSVTGTV IRTSLVKVLE FERDYMCNKC KHVFVIKADF EQYYTFCRPS SCPSLESCDS
   181  SKFTCLSGLS SSPTRCRDYQ EIKIQEQVQR LSVGSIPRSM KVILEDDLVD SCKSGDDLTI
   241  YGIVMQRWKP FQQDVRCEVE IVLKANYIQV NNEQSSGIIM DEEVQKEFED FWEYYKSDPF
   301  AGRNVILASL CPQVFGMYLV KLAVAMVLAG GIQRTDATGT RVRGESHLLL VGDPGTGKSQ
   361  FLKYAAKITP RSVLTTGIGS TSAGLTVTAV KDSGEWNLEA GALVLADAGL CCIDEFNSLK
   421  EHDRTSIHEA MEQQTISVAK AGLVCKLNTR TTILAATNPK GQYDPQESVS VNIALGSPLL
   481  SRFDLILVLL DTKNEDWDRI ISSFILENKG YPSKSEKLWS MEKMKTYFCL IRNLQPTLSD
   541  VGNQVLLRYY QMQRQSDCRN AARTTIRLLE SLIRLAEAHA RLMFRDTVTL EDAITVVSVM
   601  ESSMQGGALL GGVNALHTSF PENPGEQYQR QCELILEKLE LQSLLSEELR RLERLQNQSV
   661  HQSQPRVLEV ETTPGSLRNG PGEESNFRTS SQQEINYSTH IFSPGGSPEG SPVLDPPPHL
   721  EPNRSTSRKH SAQHKNNRDD SLDWFDFMAT HQSEPKNTVV VSPHPKTSGE NMASKISNST
   781  SQGKEKSEPG QRSKVDIGLL PSPGETGVPW RADNVESNKK KRLALDSEAA VSADKPDSVL
   841  THHVPRNLQK LCKERAQKLC RNSTRVPAQC TVPSHPQSTP VHSPDRMLDS PKRKRPKSLA
   901  QVEEPAIENV KPPGSPVAKL AKFTFKQKSK LIHSFEDHSH VSPGATKIAV HSPKISQRRT
   961  RRDAALPVKR PGKLTSTPGN QISSQPQGET KEVSQQPPEK HGPREKVMCA PEKRIIQPEL
  1021  ELGNETGCAH LTCEGDKKEE VSGSNKSGKV HACTLARLAN FCFTPPSESK SKSPPPERKN
  1081  RGERGPSSPP TTTAPMRVSK RKSFQLRGST EKLIVSKESL FTLPELGDEA FDCDWDEEMR
  1141  KKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCM9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 12 nTPM
epididymis: 9.6 nTPM
thymus: 7.4 nTPM
lymph node: 7 nTPM
tonsil: 6.7 nTPM
breast: 6.5 nTPM

Single-cell type

neutrophil progenitors: 151 nCPM
cardiomyocytes: 127 nCPM
adipocytes: 106 nCPM
myonuclei: 105 nCPM
renal collecting duct intercalated cells: 101 nCPM
microglia: 100 nCPM

Immune cell

NK-cell: 4.8 nTPM
basophil: 4.4 nTPM
eosinophil: 4.4 nTPM
T-reg: 3.5 nTPM
myeloid DC: 2.9 nTPM
neutrophil: 2.9 nTPM

Brain region

white matter: 9.4 nTPM
choroid plexus: 9.1 nTPM
midbrain: 8.7 nTPM
basal ganglia: 8.6 nTPM
medulla oblongata: 8.6 nTPM
pons: 8.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCM9.

Disease | AllUniProt

Conditions MCM9 is implicated in, by any mechanism.

Ovarian dysgenesis 4 (ODG4) MIM:616185

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

46,XX ovarian dysgenesis-short stature syndrome
Premature ovarian failure 1
Non-obstructive azoospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 1.45
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

MCM domain
AAA+ ATPase domain
Nucleic acid-binding, OB-fold
P-loop containing nucleoside triphosphate hydrolase
Mini-chromosome maintenance protein
MCM OB domain
MCM, AAA-lid domain
MCM P-loop domain
MCM OB domain
MCM AAA-lid domain
MCM9, N-terminal domain
MCM9, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCM9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCM9 as an antibody target. Whether an autoantibody or antibody against MCM9 could matter depends on whether native MCM9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCM9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCM9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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