NLRP11

Protein identityUniProt · HPA

UniProt accession

P59045

Gene

NLRP11

Ensembl

ENSG00000179873

Chromosome

19

Canonical length

1033 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1033 residues, UniProt reviewed canonical sequence.

>P59045|NLRP11
     1  MAESDSTDFD LLWYLENLSD KEFQSFKKYL ARKILDFKLP QFPLIQMTKE ELANVLPISY
    61  EGQYIWNMLF SIFSMMRKED LCRKIIGRRN RNQEACKAVM RRKFMLQWES HTFGKFHYKF
   121  FRDVSSDVFY ILQLAYDSTS YYSANNLNVF LMGERASGKT IVINLAVLRW IKGEMWQNMI
   181  SYVVHLTAHE INQMTNSSLA ELIAKDWPDG QAPIADILSD PKKLLFILED LDNIRFELNV
   241  NESALCSNST QKVPIPVLLV SLLKRKMAPG CWFLISSRPT RGNNVKTFLK EVDCCTTLQL
   301  SNGKREIYFN SFFKDRQRAS AALQLVHEDE ILVGLCRVAI LCWITCTVLK RQMDKGRDFQ
   361  LCCQTPTDLH AHFLADALTS EAGLTANQYH LGLLKRLCLL AAGGLFLSTL NFSGEDLRCV
   421  GFTEADVSVL QAANILLPSN THKDRYKFIH LNVQEFCTAI AFLMAVPNYL IPSGSREYKE
   481  KREQYSDFNQ VFTFIFGLLN ANRRKILETS FGYQLPMVDS FKWYSVGYMK HLDRDPEKLT
   541  HHMPLFYCLY ENREEEFVKT IVDALMEVTV YLQSDKDMMV SLYCLDYCCH LRTLKLSVQR
   601  IFQNKEPLIR PTASQMKSLV YWREICSLFY TMESLRELHI FDNDLNGISE RILSKALEHS
   661  SCKLRTLKLS YVSTASGFED LLKALARNRS LTYLSINCTS ISLNMFSLLH DILHEPTCQI
   721  SHLSLMKCDL RASECEEIAS LLISGGSLRK LTLSSNPLRS DGMNILCDAL LHPNCTLISL
   781  VLVFCCLTEN CCSALGRVLL FSPTLRQLDL CVNRLKNYGV LHVTFPLLFP TCQLEELHLS
   841  GCFFSSDICQ YIAIVIATNE KLRSLEIGSN KIEDAGMQLL CGGLRHPNCM LVNIGLEECM
   901  LTSACCRSLA SVLTTNKTLE RLNLLQNHLG NDGVAKLLES LISPDCVLKV VGLPLTGLNT
   961  QTQQLLMTVK ERKPSLIFLS ETWSLKEGRE IGVTPASQPG SIIPNSNLDY MFFKFPRMSA
  1021  AMRTSNTASR QPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

1.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.8

gnomAD pLI

0

gnomAD missense Z

0.65

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of inflammatory response

Molecular functions

• ATP binding
• RNA binding
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• DAPIN domain
• NACHT nucleoside triphosphatase
• Death-like domain superfamily
• Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Leucine-rich repeat domain superfamily
• NOD1/2, winged helix domain
• NACHT, LRR and PYD domains-containing protein, helical domain HD2
• NLRP family, innate immunity and inflammation regulators
• PAAD/DAPIN/Pyrin domain
• NACHT domain
• Leucine Rich repeat
• NLRC4 helical domain HD2
• NOD2 winged helix domain

KeywordsUniProt

• ATP-binding
• Leucine-rich repeat
• Nucleotide-binding
• Repeat