Seroatlas · Human Serome Atlas

SLFN13

Schlafen family member 13

Also known as: FLJ31952, SLN13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68D06
Gene: SLFN13
Ensembl: ENSG00000154760
Chromosome: 17
Canonical length: 897 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytokinetic bridge

OverviewNCBI Gene

Enables RNA endonuclease activity. Involved in rRNA catabolic process and tRNA decay. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

897 residues, UniProt reviewed canonical sequence.

>Q68D06|SLFN13
     1  MEANHCSLGV YPSYPDLVID VGEVTLGEEN RKKLQKTQRD QERARVIRAA CALLNSGGGV
    61  IQMEMANRDE RPTEMGLDLE ESLRKLIQYP YLQAFFETKQ HGRCFYIFVK SWSGDPFLKD
   121  GSFNSRICSL SSSLYCRSGT SVLHMNSRQA FDFLKTKERQ SKYNLINEGS PPSKIMKAVY
   181  QNISESNPAY EVFQTDTIEY GEILSFPESP SIEFKQFSTK HIQQYVENII PEYISAFANT
   241  EGGYLFIGVD DKSRKVLGCA KEQVDPDSLK NVIARAISKL PIVHFCSSKP RVEYSTKIVE
   301  VFCGKELYGY LCVIKVKAFC CVVFSEAPKS WMVREKYIRP LTTEEWVEKM MDADPEFPPD
   361  FAEAFESQLS LSDSPSLCRP VYSKKGLEHK ADLQQHLFPV PPGHLECTPE SLWKELSLQH
   421  EGLKELIHKQ MRPFSQGIVI LSRSWAVDLN LQEKPGVICD ALLIAQNSTP ILYTILREQD
   481  AEGQDYCTRT AFTLKQKLVN MGGYTGKVCV RAKVLCLSPE SSAEALEAAV SPMDYPASYS
   541  LAGTQHMEAL LQSLVIVLLG FRSLLSDQLG CEVLNLLTAQ QYEIFSRSLR KNRELFVHGL
   601  PGSGKTIMAM KIMEKIRNVF HCEAHRILYV CENQPLRNFI SDRNICRAET RETFLREKFE
   661  HIQHIVIDEA QNFRTEDGDW YRKAKTITQR EKDCPGVLWI FLDYFQTSHL GHSGLPPLSA
   721  QYPREELTRV VRNADEIAEY IQQEMQLIIE NPPINIPHGY LAILSEAKWV PGVPGNTKII
   781  KNFTLEQIVT YVADTCRCFF ERGYSPKDVA VLVSTVTEVE QYQSKLLKAM RKKMVVQLSD
   841  ACDMLGVHIV LDSVRRFSGL ERSIVFGIHP RTADPAILPN ILICLASRAK QHLYIFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLFN13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 31 nTPM
bone marrow: 24 nTPM
fallopian tube: 16 nTPM
parathyroid gland: 14 nTPM
spleen: 13 nTPM
tonsil: 11 nTPM

Single-cell type

breast lactating cells: 142 nCPM
fallopian tube ciliated cells: 129 nCPM
respiratory ciliated cells: 122 nCPM
nk-cells: 94 nCPM
endometrial ciliated cells: 88 nCPM
erythrocyte progenitors: 82 nCPM

Immune cell

NK-cell: 5.3 nTPM
eosinophil: 4.5 nTPM
basophil: 3.7 nTPM
gdT-cell: 1.2 nTPM
MAIT T-cell: 0.9 nTPM
memory B-cell: 0.9 nTPM

Brain region

choroid plexus: 13 nTPM
white matter: 3.9 nTPM
amygdala: 3.7 nTPM
midbrain: 3.6 nTPM
medulla oblongata: 3.3 nTPM
hypothalamus: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.69
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLFN13 as an antibody target. Whether an autoantibody or antibody against SLFN13 could matter depends on whether native SLFN13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLFN13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLFN13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...