Seroatlas · Human Serome Atlas

ATAD3C

ATPase family AAA domain-containing protein 3C

Also known as: ATD3C_HUMAN, FLJ34599

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T2N8
Gene: ATAD3C
Ensembl: ENSG00000215915
Chromosome: 1
Canonical length: 411 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitochondrion organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q5T2N8|ATAD3C
     1  MSKDALNLAQ MQEQTLQLEQ QSKLKQLVNE DLRKQEESVQ KHHQTFLESI RAAGTLFGEG
    61  FRAFVTDRDK VTATVAGLTL LAVGVYSAKN ATAVTGRYIE ARLGKPSLVR ETSRITVLEA
   121  LRHPIQQVSR RLLSRPQDVL EGVVLSPSLE ARVRDIAIMT RNIKKNRGLY RHILLYGPPG
   181  TGKTLFAKKL ALHSGMDYAI MTGGDVAPMG REGVTAMHKL FDWANTSRRG LLLFVDEADA
   241  FLRKRATEKI SEDLRATLNA FLYRTGQHSN KFMLILASCH PEQFDWAINA CIDVMVHFDL
   301  PGQEERARLV RMYLNEYVLK PATEGKRRLK LAQFDYGRKC LEIARLTEGM SCRKIAQLAV
   361  SWQATAYASK DGVLTEAMMD ACVQDFVQQH QQMMRWLKGE RPGPEDEQPS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATAD3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

liver: 5.3 nTPM
kidney: 4.4 nTPM
pancreas: 4.4 nTPM
spinal cord: 4.2 nTPM
prostate: 3.9 nTPM
thyroid gland: 3.8 nTPM

Single-cell type

oocytes: 60 nCPM
epididymal efferent duct absorptive cells: 33 nCPM
alveolar cells type 1: 28 nCPM
alveolar cells type 2: 28 nCPM
plasma cells: 25 nCPM
epididymal clear cells: 23 nCPM

Immune cell

MAIT T-cell: 1.2 nTPM
basophil: 0.7 nTPM
T-reg: 0.6 nTPM
memory B-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
NK-cell: 0.5 nTPM

Brain region

white matter: 14 nTPM
cerebral cortex: 9 nTPM
medulla oblongata: 7.9 nTPM
pons: 7.2 nTPM
basal ganglia: 7 nTPM
hypothalamus: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.82
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrion organization

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATAD3C as an antibody target. Whether an autoantibody or antibody against ATAD3C could matter depends on whether native ATAD3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATAD3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATAD3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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