Seroatlas · Human Serome Atlas

CHST2

Carbohydrate sulfotransferase 2

Also known as: C6ST, CHST2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4C5
Gene: CHST2
Ensembl: ENSG00000175040
Chromosome: 3
Canonical length: 530 aa
Protein class: Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q9Y4C5|CHST2
     1  MSRSPQRALP PGALPRLLQA APAAAPRALL PQWPRRPGRR WPASPLGMKV FRRKALVLCA
    61  GYALLLVLTM LNLLDYKWHK EPLQQCNPDG PLGAAAGAAG GSWGRPGPPP AGPPRAHARL
   121  DLRTPYRPPA AAVGAAPAAA AGMAGVAAPP GNGTRGTGGV GDKRQLVYVF TTWRSGSSFF
   181  GELFNQNPEV FFLYEPVWHV WQKLYPGDAV SLQGAARDML SALYRCDLSV FQLYSPAGSG
   241  GRNLTTLGIF GAATNKVVCS SPLCPAYRKE VVGLVDDRVC KKCPPQRLAR FEEECRKYRT
   301  LVIKGVRVFD VAVLAPLLRD PALDLKVIHL VRDPRAVASS RIRSRHGLIR ESLQVVRSRD
   361  PRAHRMPFLE AAGHKLGAKK EGVGGPADYH ALGAMEVICN SMAKTLQTAL QPPDWLQGHY
   421  LVVRYEDLVG DPVKTLRRVY DFVGLLVSPE MEQFALNMTS GSGSSSKPFV VSARNATQAA
   481  NAWRTALTFQ QIKQVEEFCY QPMAVLGYER VNSPEEVKDL SKTLLRKPRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 50 nTPM
basal ganglia: 21 nTPM
spleen: 19 nTPM
bone marrow: 16 nTPM
midbrain: 15 nTPM
cerebral cortex: 14 nTPM

Single-cell type

müller glia: 96 nCPM
decidual stromal cells: 67 nCPM
plasma cells: 66 nCPM
epididymal clear cells: 59 nCPM
nk-cells: 40 nCPM
pericytes: 32 nCPM

Immune cell

non-classical monocyte: 11 nTPM
NK-cell: 4.9 nTPM
intermediate monocyte: 4.3 nTPM
myeloid DC: 1.6 nTPM
memory B-cell: 1.1 nTPM
total PBMC: 0.9 nTPM

Brain region

white matter: 105 nTPM
medulla oblongata: 71 nTPM
thalamus: 65 nTPM
pons: 65 nTPM
spinal cord: 51 nTPM
midbrain: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.02
gnomAD missense Z: 2.14
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST2 as an antibody target. Whether an autoantibody or antibody against CHST2 could matter depends on whether native CHST2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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