Seroatlas · Human Serome Atlas

MOV10

Helicase MOV-10

Also known as: fSAP113, gb110, MGC2948, MOV10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCE1
Gene: MOV10
Ensembl: ENSG00000155363
Chromosome: 1
Canonical length: 1003 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus and mRNA destabilization. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1003 residues, UniProt reviewed canonical sequence.

>Q9HCE1|MOV10
     1  MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP APGFSSMLYG
    61  MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS KHHKSLLAKI FYDRAEYLHG
   121  KHGVDVEVQG PHEARDGQLL IRLDLNRKEV LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY
   181  NEDQELPCPL GPGECYELHV HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA
   241  VAHSPLAAQL KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL
   301  RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ MEHDIRHYDL
   361  ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL LSSETHQEDP ITYKGFVHKV
   421  ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN RQPLRVQHRA LELTGRWLLW PMLFPVAPRD
   481  VPLLPSDVKL KLYDRSLESN PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ
   541  VVKHLPKAHI LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA
   601  KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC MEPESLVAIA
   661  GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY SLLERLLTYN SLYKKGPDGY
   721  DPQFITKLLR NYRSHPTILD IPNQLYYEGE LQACADVVDR ERFCRWAGLP RQGFPIIFHG
   781  VMGKDEREGN SPSFFNPEEA ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI
   841  RYCITKLDRE LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK
   901  NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP AKLDLQQGQN
   961  LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR NEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOV10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skin: 29 nTPM
placenta: 22 nTPM
duodenum: 20 nTPM
liver: 20 nTPM
small intestine: 18 nTPM
testis: 17 nTPM

Single-cell type

sertoli cells: 144 nCPM
cytotrophoblasts: 66 nCPM
müller glia: 50 nCPM
enterocytes: 47 nCPM
migrating cytotrophoblasts: 45 nCPM
astrocytes: 44 nCPM

Immune cell

NK-cell: 13 nTPM
gdT-cell: 13 nTPM
MAIT T-cell: 13 nTPM
non-classical monocyte: 12 nTPM
memory CD8 T-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM

Brain region

hypothalamus: 12 nTPM
medulla oblongata: 8.6 nTPM
midbrain: 7.2 nTPM
thalamus: 7.2 nTPM
pons: 7.1 nTPM
choroid plexus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.81
gnomAD missense Z: 2.76
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
DNA2/NAM7 helicase, helicase domain
DNA2/NAM7 helicase-like, C-terminal
Upf1-like, C-terminal helicase domain
Helicase MOV-10-like, beta-barrel domain
AAA domain
AAA domain
Helicase MOV-10, beta-barrel domain
Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain
Helicase MOV-10, N-terminal
Helicase MOV-10, Ig-like domain
Helicase MOV-10, helical domain
Helicase MOV-10, N-terminal
Helicase MOV-10, Ig-like domain
Helicase MOV-10, helical domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOV10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOV10 as an antibody target. Whether an autoantibody or antibody against MOV10 could matter depends on whether native MOV10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOV10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOV10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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