Seroatlas · Human Serome Atlas

RAB29

Ras-related protein Rab-7L1

Also known as: RAB7L, RAB7L_HUMAN, RAB7L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14966
Gene: RAB29
Ensembl: ENSG00000117280
Chromosome: 1
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Vesicles,Cytosol

OverviewNCBI Gene

Enables several functions, including dynein complex binding activity; guanyl ribonucleotide binding activity; and kinesin binding activity. Involved in several processes, including positive regulation of T cell receptor signaling pathway; positive regulation of receptor recycling; and retrograde transport, endosome to Golgi. Located in several cellular components, including Golgi apparatus; endosome; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>O14966|RAB29
     1  MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ WSDYEIVRLQ
    61  LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ RWKQDLDSKL TLPNGEPVPC
   121  LLLANKCDLS PWAVSRDQID RFSKENGFTG WTETSVKENK NINEAMRVLI EKMMRNSTED
   181  IMSLSTQGDY INLQTKSSSW SCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

kidney: 68 nTPM
lymph node: 33 nTPM
thyroid gland: 31 nTPM
tonsil: 26 nTPM
parathyroid gland: 24 nTPM
spleen: 23 nTPM

Single-cell type

nk-cells: 77 nCPM
epididymal principal cells: 53 nCPM
epididymal efferent duct absorptive cells: 53 nCPM
hofbauer cells: 51 nCPM
salivary acinar cells: 47 nCPM
proximal tubule cells: 46 nCPM

Immune cell

NK-cell: 95 nTPM
basophil: 93 nTPM
gdT-cell: 92 nTPM
MAIT T-cell: 87 nTPM
memory CD8 T-cell: 80 nTPM
naive CD8 T-cell: 64 nTPM

Brain region

white matter: 30 nTPM
medulla oblongata: 29 nTPM
thalamus: 28 nTPM
hypothalamus: 25 nTPM
spinal cord: 25 nTPM
cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.18
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB29 as an antibody target. Whether an autoantibody or antibody against RAB29 could matter depends on whether native RAB29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB29 is annotated at the cell surface, where native RAB29 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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