Seroatlas · Human Serome Atlas

RAP2A

Ras-related protein Rap-2a

Also known as: K-REV, RAP2, RAP2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10114
Gene: RAP2A
Ensembl: ENSG00000125249
Chromosome: 13
Canonical length: 183 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including microvillus assembly; positive regulation of protein autophosphorylation; and regulation of dendrite morphogenesis. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. Is active in Schaffer collateral - CA1 synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>P10114|RAP2A
     1  MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG
    61  TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYEKVP VILVGNKVDL
   121  ESEREVSSSE GRALAEEWGC PFMETSAKSK TMVDELFAEI VRQMNYAAQP DKDDPCCSAC
   181  NIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAP2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 41 nTPM
spinal cord: 35 nTPM
amygdala: 27 nTPM
hippocampal formation: 25 nTPM
midbrain: 24 nTPM
placenta: 24 nTPM

Single-cell type

microglia: 124 nCPM
esophageal apical cells: 123 nCPM
oligodendrocyte progenitor cells: 81 nCPM
lactotrophs: 67 nCPM
gonadotrophs: 67 nCPM
cdc: 67 nCPM

Immune cell

non-classical monocyte: 2 nTPM
gdT-cell: 1.9 nTPM
plasmacytoid DC: 1.6 nTPM
naive CD8 T-cell: 1.5 nTPM
intermediate monocyte: 1.4 nTPM
memory CD8 T-cell: 1.4 nTPM

Brain region

cerebral cortex: 62 nTPM
basal ganglia: 59 nTPM
hypothalamus: 58 nTPM
white matter: 56 nTPM
spinal cord: 50 nTPM
midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.85
gnomAD missense Z: 2.56
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAP2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAP2A as an antibody target. Whether an autoantibody or antibody against RAP2A could matter depends on whether native RAP2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAP2A is annotated at the cell surface, where native RAP2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAP2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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