Seroatlas · Human Serome Atlas

DCK

Deoxycytidine kinase

Also known as: DCK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P27707
Gene: DCK
Ensembl: ENSG00000156136
Chromosome: 4
Canonical length: 260 aa
Protein class: Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>P27707|DCK
     1  MATPPKRSCP SFSASSEGTR IKKISIEGNI AAGKSTFVNI LKQLCEDWEV VPEPVARWCN
    61  VQSTQDEFEE LTMSQKNGGN VLQMMYEKPE RWSFTFQTYA CLSRIRAQLA SLNGKLKDAE
   121  KPVLFFERSV YSDRYIFASN LYESECMNET EWTIYQDWHD WMNNQFGQSL ELDGIIYLQA
   181  TPETCLHRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE
   241  DFKDKYESLV EKVKEFLSTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

thymus: 99 nTPM
lymph node: 87 nTPM
tonsil: 75 nTPM
bone marrow: 41 nTPM
appendix: 34 nTPM
spleen: 30 nTPM

Single-cell type

pdcs: 149 nCPM
monocyte progenitors: 94 nCPM
kupffer cells: 85 nCPM
erythrocyte progenitors: 82 nCPM
platelets: 79 nCPM
early primary spermatocytes: 66 nCPM

Immune cell

plasmacytoid DC: 64 nTPM
total PBMC: 45 nTPM
memory B-cell: 45 nTPM
naive B-cell: 41 nTPM
T-reg: 41 nTPM
NK-cell: 35 nTPM

Brain region

white matter: 22 nTPM
spinal cord: 18 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 17 nTPM
choroid plexus: 17 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

dAMP salvage
pyrimidine nucleotide metabolic process
nucleoside phosphate biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCK as an antibody target. Whether an autoantibody or antibody against DCK could matter depends on whether native DCK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...