Seroatlas · Human Serome Atlas

RHOG

Rho-related GTP-binding protein RhoG

Also known as: ARHG, MGC125835, MGC125836, RHOG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P84095
Gene
RHOG
Ensembl
ENSG00000177105
Chromosome
11
Canonical length
191 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>P84095|RHOG
     1  MQSIKCVVVG DGAVGKTCLL ICYTTNAFPK EYIPTVFDNY SAQSAVDGRT VNLNLWDTAG
    61  QEEYDRLRTL SYPQTNVFVI CFSIASPPSY ENVRHKWHPE VCHHCPDVPI LLVGTKKDLR
   121  AQPDTLRRLK EQGQAPITPQ QGQALAKQIH AVRYLECSAL QQDGVKEVFA EAVRAVLNPT
   181  PIKRGRSCIL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
258 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 258 nTPM
  • spleen: 164 nTPM
  • spinal cord: 128 nTPM
  • lung: 86 nTPM
  • esophagus: 82 nTPM
  • lymph node: 80 nTPM

Single-cell type

  • neutrophils: 895 nCPM
  • esophageal apical cells: 513 nCPM
  • kupffer cells: 415 nCPM
  • neutrophil progenitors: 297 nCPM
  • hofbauer cells: 274 nCPM
  • monocytes: 263 nCPM

Immune cell

  • neutrophil: 985 nTPM
  • eosinophil: 742 nTPM
  • non-classical monocyte: 565 nTPM
  • intermediate monocyte: 468 nTPM
  • basophil: 443 nTPM
  • classical monocyte: 352 nTPM

Brain region

  • white matter: 155 nTPM
  • medulla oblongata: 133 nTPM
  • basal ganglia: 123 nTPM
  • cerebellum: 114 nTPM
  • midbrain: 114 nTPM
  • pons: 111 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0.43
gnomAD missense Z
2.49
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOG as an antibody target. Whether an autoantibody or antibody against RHOG could matter depends on whether native RHOG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOG is annotated at the cell surface, where native RHOG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RHOG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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