Seroatlas · Human Serome Atlas

ABCF3

ATP-binding cassette sub-family F member 3

Also known as: ABCF3_HUMAN, EST201864

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NUQ8
Gene
ABCF3
Ensembl
ENSG00000161204
Chromosome
3
Canonical length
709 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. The protein encoded by this gene displays antiviral effect against flaviviruses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

709 residues, UniProt reviewed canonical sequence.

>Q9NUQ8|ABCF3
     1  MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE VSGDSKDDAG
    61  IRAVCQRMYN TLRLAEPQSQ GNSQVLLDAP IQLSKITENY DCGTKLPGLL KREQSSTVNA
   121  KKLEKAEARL KAKQEKRSEK DTLKTSNPLV LEEASASQAG SRKESRLESS GKNKSYDVRI
   181  ENFDVSFGDR VLLAGADVNL AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE
   241  QEVAGDDTPA LQSVLESDSV REDLLRRERE LTAQIAAGRA EGSEAAELAE IYAKLEEIEA
   301  DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL LDEPTNMLDV
   361  RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ RLDGYRGDFE TFIKSKQERL
   421  LNQQREYEAQ QQYRQHIQVF IDRFRYNANR ASQVQSKLKM LEKLPELKPV DKESEVVMKF
   481  PDGFEKFSPP ILQLDEVDFY YDPKHVIFSR LSVSADLESR ICVVGENGAG KSTMLKLLLG
   541  DLAPVRGIRH AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGRPEEEY RHQLGRYGIS
   601  GELAMRPLAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG RALNNFRGGV
   661  ILVSHDERFI RLVCRELWVC EGGGVTRVEG GFDQYRALLQ EQFRREGFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 60 nTPM
  • skeletal muscle: 50 nTPM
  • parathyroid gland: 44 nTPM
  • tongue: 42 nTPM
  • heart muscle: 30 nTPM
  • salivary gland: 28 nTPM

Single-cell type

  • syncytiotrophoblasts: 54 nCPM
  • cytotrophoblasts: 42 nCPM
  • esophageal apical cells: 38 nCPM
  • migrating cytotrophoblasts: 33 nCPM
  • adrenal cortex cells: 32 nCPM
  • extravillous trophoblasts: 30 nCPM

Immune cell

  • total PBMC: 39 nTPM
  • naive CD4 T-cell: 38 nTPM
  • MAIT T-cell: 37 nTPM
  • gdT-cell: 35 nTPM
  • non-classical monocyte: 34 nTPM
  • intermediate monocyte: 32 nTPM

Brain region

  • medulla oblongata: 34 nTPM
  • hypothalamus: 32 nTPM
  • pons: 32 nTPM
  • midbrain: 31 nTPM
  • thalamus: 31 nTPM
  • cerebral cortex: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABCF3 as an antibody target. Whether an autoantibody or antibody against ABCF3 could matter depends on whether native ABCF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABCF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABCF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABCF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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