GET3

Protein identityUniProt · HPA

UniProt accession

O43681

Gene

GET3

Ensembl

ENSG00000198356

Chromosome

19

Canonical length

348 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Nucleoli

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>O43681|GET3
     1  MAAGVAGWGV EAEEFEDAPD VEPLEPTLSN IIEQRSLKWI FVGGKGGVGK TTCSCSLAVQ
    61  LSKGRESVLI ISTDPAHNIS DAFDQKFSKV PTKVKGYDNL FAMEIDPSLG VAELPDEFFE
   121  EDNMLSMGKK MMQEAMSAFP GIDEAMSYAE VMRLVKGMNF SVVVFDTAPT GHTLRLLNFP
   181  TIVERGLGRL MQIKNQISPF ISQMCNMLGL GDMNADQLAS KLEETLPVIR SVSEQFKDPE
   241  QTTFICVCIA EFLSLYETER LIQELAKCKI DTHNIIVNQL VFPDPEKPCK MCEARHKIQA
   301  KYLDQMEDLY EDFHIVKLPL LPHEVRGADK VNTFSALLLE PYKPPSAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GET3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

85 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GET3.

Disease | AllUniProt

Conditions GET3 is implicated in, by any mechanism.

• Cardiomyopathy, dilated, 2H (CMD2H) MIM:620203

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cardiomyopathy, dilated, 2H

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.35

gnomAD pLI

0.94

DepMap mean gene effect

-0.64

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein insertion into ER membrane
• tail-anchored membrane protein insertion into ER membrane

Molecular functions

• ATP binding
• ATP hydrolysis activity
• metal ion binding
• protein carrier chaperone

Cellular components

• cytoplasm
• endoplasmic reticulum membrane
• extracellular exosome
• GET complex
• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• P-loop containing nucleoside triphosphate hydrolase
• Arsenical pump ATPase, ArsA/GET3
• ArsA/GET3, Anion-transporting ATPase-like domain
• Arsenical pump ATPase, ArsA/GET3, eukaryotic
• Anion-transporting ATPase

KeywordsUniProt

• Acetylation
• ATP-binding
• Cardiomyopathy
• Cytoplasm
• Endoplasmic reticulum
• Hydrolase
• Metal-binding
• Nucleotide-binding
• Nucleus
• Transport
• Zinc

InteractionsUniProt · HPA

Protein binding partners of GET3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAMLG
• GET4
• SEC61B
• SERP1
• STX5
• UBL4A
• VAPB