Seroatlas · Human Serome Atlas

MYO19

Unconventional myosin-XIX

Also known as: FLJ22865, MYO19_HUMAN, MYOHD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H55
Gene: MYO19
Ensembl: ENSG00000278259
Chromosome: 17
Canonical length: 970 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Enables ATP hydrolysis activity and actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

970 residues, UniProt reviewed canonical sequence.

>Q96H55|MYO19
     1  MLQQVNGHNP GSDGQAREYL REDLQEFLGG EVLLYKLDDL TRVNPVTLET VLRCLQARYM
    61  ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ KLKPHVFTVG EQTYRNVKSL
   121  IEPVNQSIVV SGESGAGKTW TSRCLMKFYA VVATSPASWE SHKIAERIEQ RILNSNPVME
   181  AFGNACTLRN NNSSRFGKFI QLQLNRAQQM TGAAVQTYLL EKTRVACQAS SERNFHIFYQ
   241  ICKGASEDER LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL
   301  AGLLHLGNIQ FAASEDEAQP CQPMDDAKYS VRTAASLLGL PEDVLLEMVQ IRTIRAGRQQ
   361  QVFRKPCARA ECDTRRDCLA KLIYARLFDW LVSVINSSIC ADTDSWTTFI GLLDVYGFES
   421  FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ QEEYAVEGLE WSFINYQDNQ PCLDLIEGSP
   481  ISICSLINEE CRLNRPSSAA QLQTRIETAL AGSPCLGHNK LSREPSFIVV HYAGPVRYHT
   541  AGLVEKNKDP IPPELTRLLQ QSQDPLLMGL FPTNPKEKTQ EEPPGQSRAP VLTVVSKFKA
   601  SLEQLLQVLH STTPHYIRCI KPNSQGQAQT FLQEEVLSQL EACGLVETIH ISAAGFPIRV
   661  SHRNFVERYK LLRRLHPCTS SGPDSPYPAK GLPEWCPHSE EATLEPLIQD ILHTLPVLTQ
   721  AAAITGDSAE AMPAPMHCGR TKVFMTDSML ELLECGRARV LEQCARCIQG GWRRHRHREQ
   781  ERQWRAVMLI QAAIRSWLTR KHIQRLHAAA TVIKRAWQKW RIRMACLAAK ELDGVEEKHF
   841  SQAPCSLSTS PLQTRLLEAI IRLWPLGLVL ANTAMGVGSF QRKLVVWACL QLPRGSPSSY
   901  TVQTAQDQAG VTSIRALPQG SIKFHCRKSP LRYADICPEP SPYSITGFNQ ILLERHRLIH
   961  VTSSAFTGLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skin: 24 nTPM
esophagus: 22 nTPM
parathyroid gland: 16 nTPM
salivary gland: 15 nTPM
vagina: 14 nTPM
stomach: 14 nTPM

Single-cell type

renal collecting duct intercalated cells: 120 nCPM
distal convoluted tubule cells: 79 nCPM
choroid plexus epithelial cells: 72 nCPM
loop of henle epithelial cells: 66 nCPM
renal connecting tubule cells: 62 nCPM
early spermatids: 55 nCPM

Immune cell

NK-cell: 1.4 nTPM
myeloid DC: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM
memory CD8 T-cell: 1.1 nTPM
MAIT T-cell: 0.9 nTPM

Brain region

choroid plexus: 6.7 nTPM
pons: 6 nTPM
white matter: 5.8 nTPM
cerebral cortex: 5.7 nTPM
medulla oblongata: 5.7 nTPM
thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin filament organization
endocytosis
mitocytosis
regulation of cytokinesis
regulation of mitochondrial fission
mitochondrion migration along actin filament

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Myosin head, motor domain-like
P-loop containing nucleoside triphosphate hydrolase
Kinesin motor domain superfamily
Myosin head (motor domain)
Class XIX myosin, motor domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYO19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MYL12B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYO19 as an antibody target. Whether an autoantibody or antibody against MYO19 could matter depends on whether native MYO19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYO19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYO19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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