Seroatlas · Human Serome Atlas

GAL3ST3

Galactose-3-O-sulfotransferase 3

Also known as: G3ST3_HUMAN, GAL3ST2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96A11
Gene
GAL3ST3
Ensembl
ENSG00000175229
Chromosome
11
Canonical length
431 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q96A11|GAL3ST3
     1  MPPILQRLQQ ATKMMSRRKI LLLVLGCSTV SLLIHQGAQL SWYPKLFPLS CPPLRNSPPR
    61  PKHMTVAFLK THKTAGTTVQ NILFRFAERH NLTVALPHPS CEHQFCYPRN FSAHFVHPAT
   121  RPPHVLASHL RFDRAELERL MPPSTVYVTI LREPAAMFES LFSYYNQYCP AFRRVPNASL
   181  EAFLRAPEAY YRAGEHFAMF AHNTLAYDLG GDNERSPRDD AAYLAGLIRQ VEEVFSLVMI
   241  AEYFDESLVL LRRLLAWDLD DVLYAKLNAR AASSRLAAIP AALARAARTW NALDAGLYDH
   301  FNATFWRHVA RAGRACVERE ARELREARQR LLRRCFGDEP LLRPAAQIRT KQLQPWQPSR
   361  KVDIMGYDLP GGGAGPATEA CLKLAMPEVQ YSNYLLRKQK RRGGARARPE PVLDNPPPRP
   421  IRVLPRGPQG P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAL3ST3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 12 nTPM
  • basal ganglia: 9.1 nTPM
  • cerebellum: 6.8 nTPM
  • cerebral cortex: 6 nTPM
  • hippocampal formation: 5.6 nTPM
  • amygdala: 5.3 nTPM

Single-cell type

  • rod photoreceptor cells: 15 nCPM
  • oligodendrocyte progenitor cells: 8 nCPM
  • brain inhibitory neurons: 7 nCPM
  • pituitary stem cells: 6.8 nCPM
  • epididymal efferent duct absorptive cells: 6.3 nCPM
  • other brain neurons: 5.2 nCPM

Immune cell

  • naive CD8 T-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • basal ganglia: 20 nTPM
  • cerebral cortex: 15 nTPM
  • cerebellum: 14 nTPM
  • hippocampal formation: 13 nTPM
  • amygdala: 11 nTPM
  • white matter: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
0.77
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAL3ST3 as an antibody target. Whether an autoantibody or antibody against GAL3ST3 could matter depends on whether native GAL3ST3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAL3ST3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAL3ST3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAL3ST3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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